PURPOSE OF REVIEW: The purpose of this review is to summarize recent advances within the area of genetic polymorphisms with a specific emphasis on renal transplantation, and to discuss the potential clinical applications. RECENT FINDINGS: Due to recent advances in molecular techniques, there has been an abundance of publications describing genetic variability in molecules relevant to transplant outcome. Many studies are now demonstrating associations between polymorphisms in these candidate genes and outcomes in organ transplantation. SUMMARY: These studies emphasize the potential role of genetic variability in transplantation, and provide the rationale for large prospective studies to clearly define the potential benefits of genotyping in the risk stratification of transplant recipients.
PURPOSE OF REVIEW: The purpose of this review is to summarize recent advances within the area of genetic polymorphisms with a specific emphasis on renal transplantation, and to discuss the potential clinical applications. RECENT FINDINGS: Due to recent advances in molecular techniques, there has been an abundance of publications describing genetic variability in molecules relevant to transplant outcome. Many studies are now demonstrating associations between polymorphisms in these candidate genes and outcomes in organ transplantation. SUMMARY: These studies emphasize the potential role of genetic variability in transplantation, and provide the rationale for large prospective studies to clearly define the potential benefits of genotyping in the risk stratification of transplant recipients.
Authors: William S Oetting; David P Schladt; Robert E Leduc; Pamala A Jacobson; Weihua Guan; Arthur J Matas; Ajay Israni Journal: Transpl Int Date: 2011-09-29 Impact factor: 3.782
Authors: William S Oetting; Yanni Zhu; Marcia J Brott; Arthur J Matas; Gretchen K Cordner; Wei Pan Journal: Clin Transplant Date: 2011-09-15 Impact factor: 2.863
Authors: Ajay Israni; Robert Leduc; John Holmes; Pamala A Jacobson; Vishal Lamba; Weihua Guan; David Schladt; Jinbo Chen; Arthur J Matas; William S Oetting Journal: Transplantation Date: 2010-12-27 Impact factor: 4.939
Authors: Yun R Li; Jessica van Setten; Shefali S Verma; Yontao Lu; Michael V Holmes; Hui Gao; Monkol Lek; Nikhil Nair; Hareesh Chandrupatla; Baoli Chang; Konrad J Karczewski; Chanel Wong; Maede Mohebnasab; Eyas Mukhtar; Randy Phillips; Vinicius Tragante; Cuiping Hou; Laura Steel; Takesha Lee; James Garifallou; Toumy Guettouche; Hongzhi Cao; Weihua Guan; Aubree Himes; Jacob van Houten; Andrew Pasquier; Reina Yu; Elena Carrigan; Michael B Miller; David Schladt; Abdullah Akdere; Ana Gonzalez; Kelsey M Llyod; Daniel McGinn; Abhinav Gangasani; Zach Michaud; Abigail Colasacco; James Snyder; Kelly Thomas; Tiancheng Wang; Baolin Wu; Alhusain J Alzahrani; Amein K Al-Ali; Fahad A Al-Muhanna; Abdullah M Al-Rubaish; Samir Al-Mueilo; Dimitri S Monos; Barbara Murphy; Kim M Olthoff; Cisca Wijmenga; Teresa Webster; Malek Kamoun; Suganthi Balasubramanian; Matthew B Lanktree; William S Oetting; Pablo Garcia-Pavia; Daniel G MacArthur; Paul I W de Bakker; Hakon Hakonarson; Kelly A Birdwell; Pamala A Jacobson; Marylyn D Ritchie; Folkert W Asselbergs; Ajay K Israni; Abraham Shaked; Brendan J Keating Journal: Genome Med Date: 2015-10-01 Impact factor: 11.117