Literature DB >> 12584360

Defects in virion production caused by mutations affecting the C-terminal portion of the Moloney murine leukemia virus capsid protein.

Margaret Q Wang1, Stephen P Goff.   

Abstract

The capsid (CA) domain of the Moloney murine leukemia virus (Mo-MuLV) Gag protein has a unique carboxy terminus with a highly charged arginine-rich sequence. Mutant viruses harboring arginine-to-alanine mutations affecting this region of CA displayed significant defects in virion release, and the few viral particles produced were noninfectious. The interaction between the mutant Gag precursors was affected, as judged by the yeast two-hybrid assay. The results suggest that the unique carboxy terminus of CA in the Mo-MuLV plays an important role in Gag-Gag association during virion production.

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Year:  2003        PMID： 12584360      PMCID： PMC149736          DOI： 10.1128/jvi.77.5.3339-3344.2003

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  37 in total

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  8 in total

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