Literature DB >> 12584353

Mumps virus decreases testosterone production and gamma interferon-induced protein 10 secretion by human leydig cells.

Ronan Le Goffic1, Thomas Mouchel, Annick Ruffault, Jean-Jacques Patard, Bernard Jégou, Michel Samson.   

Abstract

Mumps virus is responsible for sterility. Here, we show that the mumps virus infects Leydig cells in vitro and totally inhibits testosterone secretion and that ribavirin in mumps virus-infected Leydig cell cultures completely restores testosterone production. Moreover, we show that gamma interferon-induced protein 10 (IP-10) is highly expressed by mumps virus-infected Leydig cells and that ribavirin does not block IP-10 production.

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Year:  2003        PMID： 12584353      PMCID： PMC149733          DOI： 10.1128/jvi.77.5.3297-3300.2003

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  15 in total

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7.  Viral infections and implications for male reproductive health.

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Authors:  A Le Tortorec; H Denis; A-P Satie; J-J Patard; A Ruffault; B Jégou; N Dejucq-Rainsford
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9.  Mumps virus-induced innate immune responses in mouse Sertoli and Leydig cells.

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Journal:  J Virol       Date:  2018-09-12       Impact factor: 5.103
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