Literature DB >> 12581669

Ras-effector interactions: after one decade.

Christian Herrmann1.   

Abstract

Ras effectors have convergently developed a common subdomain in their otherwise unrelated protein body for their interaction with Ras. Structural analysis revealed that the mode of interaction is highly similar for all Ras effectors, but is completely different from that of effectors of other subfamilies of small GTPases. Whereas the molecular mechanism of effector activation is still elusive, detailed knowledge about the thermodynamics and dynamics of the interaction with Ras has accumulated.

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Year:  2003        PMID： 12581669     DOI： 10.1016/s0959-440x(02)00007-6

Source DB:  PubMed          Journal:  Curr Opin Struct Biol        ISSN： 0959-440X            Impact factor:   6.809


  58 in total

1.  Electrostatically optimized Ras-binding Ral guanine dissociation stimulator mutants increase the rate of association by stabilizing the encounter complex.

Authors:  C Kiel; T Selzer; Y Shaul; G Schreiber; C Herrmann
Journal:  Proc Natl Acad Sci U S A       Date:  2004-06-14       Impact factor: 11.205

Review 2.  Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view.

Authors:  Shaoyong Lu; Hyunbum Jang; Shuo Gu; Jian Zhang; Ruth Nussinov
Journal:  Chem Soc Rev       Date:  2016-07-11       Impact factor: 54.564

Review 3.  Ras nanoclusters: molecular structure and assembly.

Authors:  Daniel Abankwa; Alemayehu A Gorfe; John F Hancock
Journal:  Semin Cell Dev Biol       Date:  2007-08-19       Impact factor: 7.727

4.  Differences in the regulation of K-Ras and H-Ras isoforms by monoubiquitination.

Authors:  Rachael Baker; Emily M Wilkerson; Kazutaka Sumita; Daniel G Isom; Atsuo T Sasaki; Henrik G Dohlman; Sharon L Campbell
Journal:  J Biol Chem       Date:  2013-11-18       Impact factor: 5.157

5.  K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to gamma-secretase inhibitors.

Authors:  Thomas Kindler; Melanie G Cornejo; Claudia Scholl; Jianing Liu; Dena S Leeman; J Erika Haydu; Stefan Fröhling; Benjamin H Lee; D Gary Gilliland
Journal:  Blood       Date:  2008-07-28       Impact factor: 22.113

6.  Improved binding of raf to Ras.GDP is correlated with biological activity.

Authors:  Christina Kiel; Daniel Filchtinski; Michael Spoerner; Gideon Schreiber; Hans Robert Kalbitzer; Christian Herrmann
Journal:  J Biol Chem       Date:  2009-09-23       Impact factor: 5.157

7.  Ras membrane orientation and nanodomain localization generate isoform diversity.

Authors:  Daniel Abankwa; Alemayehu A Gorfe; Kerry Inder; John F Hancock
Journal:  Proc Natl Acad Sci U S A       Date:  2010-01-04       Impact factor: 11.205

8.  The distinct conformational dynamics of K-Ras and H-Ras A59G.

Authors:  Suryani Lukman; Barry J Grant; Alemayehu A Gorfe; Guy H Grant; J Andrew McCammon
Journal:  PLoS Comput Biol       Date:  2010-09-09       Impact factor: 4.475

9.  Ras homolog enriched in brain (Rheb) enhances apoptotic signaling.

Authors:  Sascha Karassek; Carsten Berghaus; Melanie Schwarten; Christoph G Goemans; Nadine Ohse; Gerd Kock; Katharina Jockers; Sebastian Neumann; Sebastian Gottfried; Christian Herrmann; Rolf Heumann; Raphael Stoll
Journal:  J Biol Chem       Date:  2010-08-04       Impact factor: 5.157

10.  A Rap/phosphatidylinositol 3-kinase pathway controls pseudopod formation [corrected].

Authors:  Arjan Kortholt; Parvin Bolourani; Holger Rehmann; Ineke Keizer-Gunnink; Gerald Weeks; Alfred Wittinghofer; Peter J M Van Haastert
Journal:  Mol Biol Cell       Date:  2010-01-20       Impact factor: 4.138
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