Literature DB >> 12581665

Single-molecule folding.

Xiaowei Zhuang1, Matthias Rief.   

Abstract

Recent developments in fluorescence and force spectroscopy enable us to go beyond the ensemble average and measure the behavior of individual biomacromolecules. These single-molecule approaches can directly resolve transient intermediate states and multiple reaction pathways, and thus are uniquely powerful in characterizing the complex dynamics of biological processes. Recent applications of these two techniques to the protein and RNA folding problems have led to exciting new results.

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Year:  2003        PMID： 12581665     DOI： 10.1016/s0959-440x(03)00011-3

Source DB:  PubMed          Journal:  Curr Opin Struct Biol        ISSN： 0959-440X            Impact factor:   6.809


  52 in total

1.  Single-molecule enzymology of RNA: essential functional groups impact catalysis from a distance.

Authors:  David Rueda; Gregory Bokinsky; Maria M Rhodes; Michael J Rust; Xiaowei Zhuang; Nils G Walter
Journal:  Proc Natl Acad Sci U S A       Date:  2004-06-24       Impact factor: 11.205

2.  Pulling-speed-dependent force-extension profiles for semiflexible chains.

Authors:  Nam-Kyung Lee; D Thirumalai
Journal:  Biophys J       Date:  2004-05       Impact factor: 4.033

3.  Electrical detection of single viruses.

Authors:  Fernando Patolsky; Gengfeng Zheng; Oliver Hayden; Melike Lakadamyali; Xiaowei Zhuang; Charles M Lieber
Journal:  Proc Natl Acad Sci U S A       Date:  2004-09-13       Impact factor: 11.205

4.  Measuring single-molecule nucleic acid dynamics in solution by two-color filtered ratiometric fluorescence correlation spectroscopy.

Authors:  Haitao Li; Xiaojun Ren; Liming Ying; Shankar Balasubramanian; David Klenerman
Journal:  Proc Natl Acad Sci U S A       Date:  2004-09-27       Impact factor: 11.205

5.  Efficient fluorescence labeling of a large RNA through oligonucleotide hybridization.

Authors:  Glenna J Smith; Tobin R Sosnick; Norbert F Scherer; Tao Pan
Journal:  RNA       Date:  2004-12-21       Impact factor: 4.942

6.  The folding pathway of a fast-folding immunoglobulin domain revealed by single-molecule mechanical experiments.

Authors:  Ingo Schwaiger; Michael Schleicher; Angelika A Noegel; Matthias Rief
Journal:  EMBO Rep       Date:  2005-01       Impact factor: 8.807

7.  Accurate FRET measurements within single diffusing biomolecules using alternating-laser excitation.

Authors:  Nam Ki Lee; Achillefs N Kapanidis; You Wang; Xavier Michalet; Jayanta Mukhopadhyay; Richard H Ebright; Shimon Weiss
Journal:  Biophys J       Date:  2005-01-14       Impact factor: 4.033

8.  Multiple membrane tethers probed by atomic force microscopy.

Authors:  Mingzhai Sun; John S Graham; Balazs Hegedüs; Françoise Marga; Ying Zhang; Gabor Forgacs; Michel Grandbois
Journal:  Biophys J       Date:  2005-09-23       Impact factor: 4.033

9.  Ensemble versus single-molecule protein unfolding.

Authors:  Ryan Day; Valerie Daggett
Journal:  Proc Natl Acad Sci U S A       Date:  2005-09-09       Impact factor: 11.205

10.  Single adhesive nanofibers from a live diatom have the signature fingerprint of modular proteins.

Authors:  T M Dugdale; R Dagastine; A Chiovitti; P Mulvaney; R Wetherbee
Journal:  Biophys J       Date:  2005-09-16       Impact factor: 4.033
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