BACKGROUND: Calcifying odontogenic cyst (COC) is an uncommon odontogenic lesion with few studies describing its immunohistochemical profile and proliferative activity reported in the literature. METHODS: Clinical and histological features and immunohistochemical expression of cytokeratins, Mel-CAM (CD146), bcl-2, PCNA and ki-67, in 10 cases of COC were studied. RESULTS: All 10 cases affected the maxilla, eight intraosseous and two peripheral. Five central cases were cystic and three were cystic associated with odontoma, and the two extraosseous showed solid histological pattern; immunohistochemistry was positive for cytokeratins 8, 14, 19, AE1/AE3 and 34betaE12 and bcl-2 in all cases, and Mel-CAM in six cases. Proliferative activity was greater in the epithelium of central cystic COC in relation to COC associated with odontoma and peripheral lesions. CONCLUSION: Calcifying odontogenic cysts showed odontogenic cytokeratin profile and bcl-2 and Mel-CAM expression indicate that these proteins may be involved in the development of COC. There were no recurrences after surgery, irrespective of their proliferative activity.
BACKGROUND: Calcifying odontogenic cyst (COC) is an uncommon odontogenic lesion with few studies describing its immunohistochemical profile and proliferative activity reported in the literature. METHODS: Clinical and histological features and immunohistochemical expression of cytokeratins, Mel-CAM (CD146), bcl-2, PCNA and ki-67, in 10 cases of COC were studied. RESULTS: All 10 cases affected the maxilla, eight intraosseous and two peripheral. Five central cases were cystic and three were cystic associated with odontoma, and the two extraosseous showed solid histological pattern; immunohistochemistry was positive for cytokeratins 8, 14, 19, AE1/AE3 and 34betaE12 and bcl-2 in all cases, and Mel-CAM in six cases. Proliferative activity was greater in the epithelium of central cystic COC in relation to COC associated with odontoma and peripheral lesions. CONCLUSION: Calcifying odontogenic cysts showed odontogenic cytokeratin profile and bcl-2 and Mel-CAM expression indicate that these proteins may be involved in the development of COC. There were no recurrences after surgery, irrespective of their proliferative activity.
Authors: Dardo Menditti; Luigi Laino; Marina DI Domenico; Giuseppe Troiano; Mario Guglielmotti; Sara Sava; Antonio Mezzogiorno; Alfonso Baldi Journal: In Vivo Date: 2018 Sep-Oct Impact factor: 2.155
Authors: Yuri Slusarenko da Silva; Adalmir Gonzaga Dos Santos Queiroz; Flávio Wellington da Silva Ferraz; Décio Dos Santos Pinto; Fabio Daumas Nunes; Fernando Mellhem Elias Journal: Autops Case Rep Date: 2014-03-30
Authors: Ana Paula de Lima; Dárcio Kitakawa; Janete Dias Almeida; Adriana Aigotti Haberbeck Brandão; Ana Lia Anbinder Journal: BMC Res Notes Date: 2012-08-23
Authors: Hellen Bandeira de Pontes Santos; Everton Freitas de Morais; Deborah Gondim Lambert Moreira; Luis Ferreira de Almeida Neto; Petrus Pereira Gomes; Roseana de Almeida Freitas Journal: Case Rep Pathol Date: 2018-05-10