Monisha Goyal1, Barbara A Bangert, Max Wiznitzer. 1. Department of Pediatrics, Division of Pediatric Neurology, Rainbow Babies and Children's Hospital, Cleveland, OH 44106-6005, USA. mongoyal98@yahoo.com
Abstract
PURPOSE: Although seizures are relatively common in acute childhood leukemias, evolution into epilepsy is rare. METHODS: We describe three patients with acute leukemias who received chemotherapy. One patient also received cranial irradiation. RESULTS: All three developed recurrent complex partial seizures after initiation of chemotherapy. Initial neuroimaging performed in two patients was normal. Subsequent neuroimaging in all three revealed mesial temporal sclerosis. CONCLUSIONS: The association of mesial temporal sclerosis in acute childhood leukemias has not been previously described and may be secondary to antileukemic treatment and recurrent seizures.
PURPOSE: Although seizures are relatively common in acute childhood leukemias, evolution into epilepsy is rare. METHODS: We describe three patients with acute leukemias who received chemotherapy. One patient also received cranial irradiation. RESULTS: All three developed recurrent complex partial seizures after initiation of chemotherapy. Initial neuroimaging performed in two patients was normal. Subsequent neuroimaging in all three revealed mesial temporal sclerosis. CONCLUSIONS: The association of mesial temporal sclerosis in acute childhood leukemias has not been previously described and may be secondary to antileukemic treatment and recurrent seizures.