| Literature DB >> 12580965 |
Robin Foa1, Antonella Vitale, Marco Mancini, Antonio Cuneo, Cristina Mecucci, Loredana Elia, Romina Lombardo, Giuseppe Saglio, Giuseppe Torelli, Luciana Annino, Giorgina Specchia, Eugenio Damasio, Anna Recchia, Francesco Di Raimondo, Enrica Morra, Ettore Volpe, Agostino Tafuri, Paola Fazi, Stephen P Hunger, Franco Mandelli.
Abstract
Molecular and cytogenetic studies performed in 305 adult acute lymphoblastic leukaemia (ALL) patients enrolled in the gimema (Gruppo Italiano Malattie EMatologiche dell'Adulto) multicentric protocols identified an E2A-PBX1 fusion and/or t(1;19) in 10 patients (3.3%). All had common ALL, were mostly CyIg+ and were CD34/CD13/CD33-. Nine patients achieved a complete remission (CR); five patients showed a haematological relapse after 7 months (median). Four patients are alive in first CR with a median follow-up of 29 months; three patients are molecularly negative. This abnormality is frequently associated with early treatment failure. E2A-PBX1+ adult ALL should be considered for intensified treatment strategies and monitoring of minimal residual disease.Entities:
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Year: 2003 PMID： 12580965 DOI： 10.1046/j.1365-2141.2003.04113.x
Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998