OBJECTIVE: To determine the relationship between the apolipoprotein E (APOE) epsilon4 allele and in-hospital mortality from intracerebral haemorrhage (ICH). MATERIAL AND METHODS: Patients admitted to two acute stroke units with ICH were prospectively evaluated and APOE genotyped. In-hospital survival was recorded in 176 patients. RESULTS: There were 85 men and 91 women, mean age 68 years. Fifty-two (30%) of the 176 patients died in hospital. After adjusting for sex, age, hospital, and race, increased age (P = 0.009) and the presence of the APOEepsilon4 allele (P = 0.026) significantly reduced in-hospital survival. CONCLUSION: The APOEepsilon4 allele in this population may be associated with poor survival following ICH.
OBJECTIVE: To determine the relationship between the apolipoprotein E (APOE) epsilon4 allele and in-hospital mortality from intracerebral haemorrhage (ICH). MATERIAL AND METHODS:Patients admitted to two acute stroke units with ICH were prospectively evaluated and APOE genotyped. In-hospital survival was recorded in 176 patients. RESULTS: There were 85 men and 91 women, mean age 68 years. Fifty-two (30%) of the 176 patients died in hospital. After adjusting for sex, age, hospital, and race, increased age (P = 0.009) and the presence of the APOEepsilon4 allele (P = 0.026) significantly reduced in-hospital survival. CONCLUSION: The APOEepsilon4 allele in this population may be associated with poor survival following ICH.
Authors: Ludmila Pawlikowska; K Y Trudy Poon; Achal S Achrol; Charles E McCulloch; Connie Ha; Kristen Lum; Jonathan G Zaroff; Nerissa U Ko; S Claiborne Johnston; Stephen Sidney; Douglas A Marchuk; Michael T Lawton; Pui-Yan Kwok; William L Young Journal: Neurosurgery Date: 2006-05 Impact factor: 4.654
Authors: Michael L James; Patrick M Sullivan; Christopher D Lascola; Michael P Vitek; Daniel T Laskowitz Journal: Stroke Date: 2008-12-24 Impact factor: 7.914
Authors: Beilei Lei; Brian Mace; Steven T Bellows; Patrick M Sullivan; Michael P Vitek; Daniel T Laskowitz; Michael L James Journal: Transl Stroke Res Date: 2012-03 Impact factor: 6.829