AIM: To study the pharmacokinetics of 20 (R)-ginsenoside Rg3 (GRg3) in human. METHODS: High-performance liquid chromatography-ultraviolet detection method was used in this study. RESULTS: The pharmacokinetics of GRg3 in 14 healthy volunteers were investigated. After a single oral dose of 3.2 mg.kg-1 in 8 male volunteers, the plasma concentration-time course fitted well to a two-compartment open model, with the following pharmacokinetic parameters: Tmax(0.66 +/- 0.10) h, Cmax(16 +/- 6) ng.mL-1, T1/2 alpha(0.46 +/- 0.12) h, T1/2 beta(4.9 +/- 1.1) h, T1/2(Ka)(0.28 +/- 0.04) h, AUC0-infinity(77 +/- 26) ng.mL-1.h. No kinetic analysis was made after an oral dose of 0.8 mg.kg-1 GRg3 in 6 other volunteers because of the low concentration, but a good correlation between Cmax and dosage of the two groups was found. CONCLUSION: The absorption of GRg3 was rapid in man, and its elimination was rapid after oral administration of ginsenoside Rg3. The pharmacokinetic results shows that it exhibited first order kinetic characteristics.
AIM: To study the pharmacokinetics of 20 (R)-ginsenoside Rg3 (GRg3) in human. METHODS: High-performance liquid chromatography-ultraviolet detection method was used in this study. RESULTS: The pharmacokinetics of GRg3 in 14 healthy volunteers were investigated. After a single oral dose of 3.2 mg.kg-1 in 8 male volunteers, the plasma concentration-time course fitted well to a two-compartment open model, with the following pharmacokinetic parameters: Tmax(0.66 +/- 0.10) h, Cmax(16 +/- 6) ng.mL-1, T1/2 alpha(0.46 +/- 0.12) h, T1/2 beta(4.9 +/- 1.1) h, T1/2(Ka)(0.28 +/- 0.04) h, AUC0-infinity(77 +/- 26) ng.mL-1.h. No kinetic analysis was made after an oral dose of 0.8 mg.kg-1 GRg3 in 6 other volunteers because of the low concentration, but a good correlation between Cmax and dosage of the two groups was found. CONCLUSION: The absorption of GRg3 was rapid in man, and its elimination was rapid after oral administration of ginsenoside Rg3. The pharmacokinetic results shows that it exhibited first order kinetic characteristics.
Authors: Elena Jovanovski; Lea Smircic-Duvnjak; Allison Komishon; Fei Rodney Au-Yeung; John L Sievenpiper; Andreea Zurbau; Alexandra L Jenkins; Mi-Kyung Sung; Robert Josse; Dandan Li; Vladimir Vuksan Journal: J Ginseng Res Date: 2019-11-14 Impact factor: 6.060
Authors: Philippa A Jackson; Emma L Wightman; Rachel Veasey; Joanne Forster; Julie Khan; Caroline Saunders; Siobhan Mitchell; Crystal F Haskell-Ramsay; David O Kennedy Journal: Nutrients Date: 2020-07-28 Impact factor: 5.717