Literature DB >> 12579999

Quantitative analysis of serum free light chains. A new marker for the diagnostic evaluation of primary systemic amyloidosis.

Roshini S Abraham1, Jerry A Katzmann, Raynell J Clark, A R Bradwell, Robert A Kyle, Morie A Gertz.   

Abstract

Primary systemic amyloidosis is a plasma cell dyscrasia characterized by the accumulation of excess free immunoglobulin light chains (FLCs) as amyloid. One of the diagnostic features of amyloidosis is the presence of circulating monoclonal FLCs in the serum and urine of the patients. The FLC usually is present in small amounts, and immunofixation is required for detection. A nephelometric method for quantitating FLCs in serum has been described using antibodies that recognize only FLC not bound to heavy chain. We describe a retrospective study using this quantitative FLC method for assessing monoclonal FLCs in 95 patients with amyloidosis. The sensitivity of nephelometric serum FLC measurements is particularly useful in patients with negative immunofixation results for serum, urine, or both. In addition, the FLC assay can be used for follow-up of patients with amyloidosis who have undergone stem cell transplantation.

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Year:  2003        PMID： 12579999     DOI： 10.1309/LYWM-47K2-L8XY-FFB3

Source DB:  PubMed          Journal:  Am J Clin Pathol        ISSN： 0002-9173            Impact factor:   2.493


  27 in total

1.  Serum immunoglobulin free light-chain measurement in primary amyloidosis: prognostic value and correlations with clinical features.

Authors:  Shaji Kumar; Angela Dispenzieri; Jerry A Katzmann; Dirk R Larson; Colin L Colby; Martha Q Lacy; Suzanne R Hayman; Francis K Buadi; Nelson Leung; Steve R Zeldenrust; Marina Ramirez-Alvarado; Raynell J Clark; Robert A Kyle; S Vincent Rajkumar; Morie A Gertz
Journal:  Blood       Date:  2010-08-26       Impact factor: 22.113

2.  Elevated serum free light chains are associated with inferior event free and overall survival in Hodgkin lymphoma.

Authors:  Carrie A Thompson; Matthew J Maurer; James R Cerhan; Jerry A Katzmann; Stephen M Ansell; Thomas M Habermann; William R Macon; George J Weiner; Brian K Link; Thomas E Witzig
Journal:  Am J Hematol       Date:  2011-10-17       Impact factor: 10.047

3.  Absolute values of immunoglobulin free light chains are prognostic in patients with primary systemic amyloidosis undergoing peripheral blood stem cell transplantation.

Authors:  Angela Dispenzieri; Martha Q Lacy; Jerry A Katzmann; S Vincent Rajkumar; Roshini S Abraham; Suzanne R Hayman; Shaji K Kumar; Raynell Clark; Robert A Kyle; Mark R Litzow; David J Inwards; Stephen M Ansell; Ivana M Micallef; Luis F Porrata; Michelle A Elliott; Patrick B Johnston; Philip R Greipp; Thomas E Witzig; Steven R Zeldenrust; Stephen J Russell; Dennis Gastineau; Morie A Gertz
Journal:  Blood       Date:  2006-01-05       Impact factor: 22.113

4.  Detection of kappa and lambda light chain monoclonal proteins in human serum: automated immunoassay versus immunofixation electrophoresis.

Authors:  Troy D Jaskowski; Christine M Litwin; Harry R Hill
Journal:  Clin Vaccine Immunol       Date:  2006-02

5.  Appraisal of immunoglobulin free light chain as a marker of response.

Authors:  Angela Dispenzieri; Lijun Zhang; Jerry A Katzmann; Melissa Snyder; Emily Blood; Roberta Degoey; Kimberly Henderson; Robert A Kyle; Martin M Oken; Arthur R Bradwell; Philip R Greipp
Journal:  Blood       Date:  2008-03-25       Impact factor: 22.113

6.  Short-term effect of levosimendan on free light chain kappa and lambda levels in patients with decompensated chronic heart failure.

Authors:  Ibrahim Halil Kurt; Kemal Yavuzer; Mustafa Kemal Batur
Journal:  Heart Vessels       Date:  2010-07-31       Impact factor: 2.037

7.  Advanced cardiac amyloidosis associated with normal interventricular septal thickness: an uncommon presentation of infiltrative cardiomyopathy.

Authors:  Rahul Suresh; Martha Grogan; Joseph J Maleszewski; Patricia A Pellikka; Mazen Hanna; Angela Dispenzieri; Naveen L Pereira
Journal:  J Am Soc Echocardiogr       Date:  2014-01-18       Impact factor: 5.251

8.  Serum immunoglobulin free light chain assessment in rheumatoid arthritis and primary Sjogren's syndrome.

Authors:  J-E Gottenberg; F Aucouturier; J Goetz; C Sordet; I Jahn; M Busson; J-M Cayuela; J Sibilia; X Mariette
Journal:  Ann Rheum Dis       Date:  2006-03-28       Impact factor: 19.103

9.  Immunodiagnostic capabilities of anti-free immunoglobulin light chain monoclonal antibodies.

Authors:  Sandra Davern; Lian X Tang; Teresa K Williams; Sallie D Macy; Jonathan S Wall; Deborah T Weiss; Alan Solomon
Journal:  Am J Clin Pathol       Date:  2008-11       Impact factor: 2.493

Review 10.  New advances in renal amyloidosis.

Authors:  Shinichi Nishi; Bassam Alchi; Nofumi Imai; Fumitake Gejyo
Journal:  Clin Exp Nephrol       Date:  2008-01-05       Impact factor: 2.801
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