C X Zhou1, X H Li. 1. Department of Chemistry, Zhejiang University, Hangzhou 310027, China. cxzhou@css.zju.edu.cn
Abstract
AIM: To study the stability of ligustilide with solvent effect and try to disclose the relationship between its stability and solvent effect, so as to develop a useful method for its preservation. METHODS: The model of PCM solvent effect was used to carry out quantum chemistry calculation. The GC/MS spectrum was used to study the stability of ligustilide in solvent at room temperature. RESULTS: Ligustilide is more stable in cyclohexane and chloroform than in air. The isomerization rate of ligustilide decreased remarkably to 1.6% and 6.7% in cyclohexane and chloroform compared to 58% in air. CONCLUSION: The stability of ligustilide is greatly improved with the solvent effect. Keeping ligustilide in proper organic solvent is helpful to prevent its isomerization.
AIM: To study the stability of ligustilide with solvent effect and try to disclose the relationship between its stability and solvent effect, so as to develop a useful method for its preservation. METHODS: The model of PCM solvent effect was used to carry out quantum chemistry calculation. The GC/MS spectrum was used to study the stability of ligustilide in solvent at room temperature. RESULTS:Ligustilide is more stable in cyclohexane and chloroform than in air. The isomerization rate of ligustilide decreased remarkably to 1.6% and 6.7% in cyclohexane and chloroform compared to 58% in air. CONCLUSION: The stability of ligustilide is greatly improved with the solvent effect. Keeping ligustilide in proper organic solvent is helpful to prevent its isomerization.
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