PURPOSE: To discuss the role of postoperative radiation therapy (RT) for patients with squamous cell carcinoma of the head and neck. RESULTS: Patients with adverse pathologic features have a high likelihood of local-regional recurrence and a decreased probability of survival after surgery alone. Postoperative RT reduces the risk of local-regional failure and probably improves survival. Patients who are at high risk for recurrence after surgery benefit from more aggressive dose-fractionation schedules that may include altered fractionation to decrease the overall time from surgery to the completion of RT. Adjuvant chemotherapy also appears to improve the probability of cure in high risk patients. CONCLUSION: Patients who have a high likelihood of local-regional recurrence after surgery have improved disease control and survival after postoperative RT. Copyright 2003, Elsevier Science (USA). All rights reserved.)
PURPOSE: To discuss the role of postoperative radiation therapy (RT) for patients with squamous cell carcinoma of the head and neck. RESULTS:Patients with adverse pathologic features have a high likelihood of local-regional recurrence and a decreased probability of survival after surgery alone. Postoperative RT reduces the risk of local-regional failure and probably improves survival. Patients who are at high risk for recurrence after surgery benefit from more aggressive dose-fractionation schedules that may include altered fractionation to decrease the overall time from surgery to the completion of RT. Adjuvant chemotherapy also appears to improve the probability of cure in high risk patients. CONCLUSION:Patients who have a high likelihood of local-regional recurrence after surgery have improved disease control and survival after postoperative RT. Copyright 2003, Elsevier Science (USA). All rights reserved.)
Authors: William M Mendenhall; Primož Strojan; Carl E Silver; Randall P Owen; Alessandra Rinaldo; Ashok R Shaha; Avraham Eisbruch; Robert P Takes; Alfio Ferlito Journal: Eur Arch Otorhinolaryngol Date: 2013-10-20 Impact factor: 2.503
Authors: K C Lakshmaiah; T M Suresh; K Govind Babu; Nagesh T Sirsath; Lokanatha Dasappa; Linu Jacob Abraham Journal: South Asian J Cancer Date: 2015 Apr-Jun
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