Literature DB >> 12579276

Preoperative combination chemotherapy with S-1 and low dose cisplatin against highly advanced gastric carcinoma.

Yoshiro Saikawa1, Yoshikiyo Akasaka, Toshio Kanai, Yoshihide Otani, Koichiro Kumai, Tetsuro Kubota, Masaki Kitajima.   

Abstract

We performed preoperative chemotherapy with S-1 and low-dose CDDP (TSLD) to treat 9 patients of highly advanced gastric cancer. Five cases showed significant effect with severe fibrosis diagnosed as grade 1b-2 effect in histology, and all 9 cases showed at least grade 1a effect in either primary lesion or lymph node. While toxicity of less than grade 3 (gastrointestinal disorder and/or bone marrow suppression) were observed in 5 out of 9 cases (55.6%), no symptom was observed in 3 out of the 5 patients. We conclude that the TSLD is useful to control highly advanced gastric cancer.

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Year:  2003        PMID： 12579276

Source DB:  PubMed          Journal:  Oncol Rep        ISSN： 1021-335X            Impact factor:   3.906


  5 in total

1.  Complete response to preoperative chemoradiotherapy in highly advanced gastric adenocarcinoma.

Authors:  Hironori Shigeoka; Haruhiko Imamoto; Yasumasa Nishimura; Taro Shimono; Hiroshi Furukawa; Hiroshi Imamura; Takushi Yasuda; Hitoshi Shiozaki
Journal:  World J Gastrointest Oncol       Date:  2010-06-15

2.  Octreotide acetate enables the administration of chemoradiotherapy, including the oral anticancer drug S-1, in gastric cancer patients with malignant gastrointestinal obstruction.

Authors:  Tsunehiro Takahashi; Yoshiro Saikawa; Takahiro Igarashi; Shinichi Tsuwano; Koshi Kumagai; Rieko Nakamura; Takashi Ooyama; Norihito Wada; Hiroya Takeuchi; Hiromasa Takaishi; Yuko Kitagawa
Journal:  Oncol Lett       Date:  2010-07-01       Impact factor: 2.967

3.  Octreotide acetate successfully treated a bowel obstruction caused by peritoneally disseminated gastric cancer, thereby enabling the subsequent use of oral S-1 chemotherapy.

Authors:  Koshi Kumagai; Yoshiro Saikawa; Kazumasa Fukuda; Ryo Ito; Takahiro Igarashi; Shinichi Tsuwano; Rieko Nakamura; Tsunehiro Takahashi; Hiroya Takeuchi; Yuko Kitagawa
Journal:  Int J Clin Oncol       Date:  2009-08-25       Impact factor: 3.402

4.  A patient with gastric cancer and liver metastases successfully treated with combination chemotherapy including S-1.

Authors:  Rieko Nakamura; Yoshiro Saikawa; Koushi Kumagai; Tsuyoshi Kiyota; Masaki Ohashi; Masashi Yoshida; Tetsuro Kubota; Koichiro Kumai; Masaki Kitajima
Journal:  Int J Clin Oncol       Date:  2007-08-20       Impact factor: 3.402

5.  Retrospective analysis of prognosis for scirrhous-type gastric cancer: one institution's experience.

Authors:  Rieko Nakamura; Yoshiro Saikawa; Norihito Wada; Masashi Yoshida; Tetsuro Kubota; Koichiro Kumai; Masaki Kitajima
Journal:  Int J Clin Oncol       Date:  2007-08-20       Impact factor: 3.402
  5 in total

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