BACKGROUND: Adverse drug events (ADEs) are noxious and unintended results of drug therapy. ADEs have been shown to be a risk to hospitalized patients. The purpose of this study was to determine the rate and nature of ADEs in trauma patients and to characterize the population at risk. METHODS: An electronic medical record, a hospital wide computerized surveillance program, and a clinical pharmacist prospectively investigated ADEs in 4,320 trauma patients from 1996 through 1999. RESULTS: The rate of ADEs in trauma patients (98/4320, 2.3%) was twice that of non-trauma hospital patients (1,111/96,218, 1.2%, p < 0.001). Traumatized females had ADEs 1.5 times more often than traumatized males (2.7% versus 1.8%, p = 0.052). The medication class most often associated with ADEs was analgesics with 54% involving morphine and 20% involving meperidine. The most common ADEs were nausea, vomiting, and itching. Only one ADE was directly attributed to a medical error. CONCLUSIONS: Trauma patients are at double the risk for ADEs. Analgesics are particularly associated with ADEs and use should be carefully monitored.
BACKGROUND: Adverse drug events (ADEs) are noxious and unintended results of drug therapy. ADEs have been shown to be a risk to hospitalized patients. The purpose of this study was to determine the rate and nature of ADEs in traumapatients and to characterize the population at risk. METHODS: An electronic medical record, a hospital wide computerized surveillance program, and a clinical pharmacist prospectively investigated ADEs in 4,320 traumapatients from 1996 through 1999. RESULTS: The rate of ADEs in traumapatients (98/4320, 2.3%) was twice that of non-trauma hospital patients (1,111/96,218, 1.2%, p < 0.001). Traumatized females had ADEs 1.5 times more often than traumatized males (2.7% versus 1.8%, p = 0.052). The medication class most often associated with ADEs was analgesics with 54% involving morphine and 20% involving meperidine. The most common ADEs were nausea, vomiting, and itching. Only one ADE was directly attributed to a medical error. CONCLUSIONS:Traumapatients are at double the risk for ADEs. Analgesics are particularly associated with ADEs and use should be carefully monitored.
Authors: Carla F Justiniano; David C Evans; Charles H Cook; Daniel S Eiferman; Anthony T Gerlach; Paul R Beery; David E Lindsey; Gary E A Saum; Claire V Murphy; Sidney F Miller; Thomas J Papadimos; Steven M Steinberg; Stanislaw P A Stawicki Journal: J Surg Res Date: 2012-05-31 Impact factor: 2.192
Authors: Ronnie N Mubang; Jill C Stoltzfus; Marissa S Cohen; Brian A Hoey; Christy D Stehly; David C Evans; Christian Jones; Thomas J Papadimos; Jennifer Grell; William S Hoff; Peter Thomas; James Cipolla; Stanislaw P Stawicki Journal: World J Surg Date: 2015-08 Impact factor: 3.352
Authors: Maya A Ramrattan; Eveline B Boeker; Kim Ram; Desiree M T Burgers; Monica de Boer; Loraine Lie-A-Huen; Wilhelmina M C Mulder; Marja A Boermeester Journal: Int J Clin Pharm Date: 2014-04-20
Authors: Monica de Boer; Eveline B Boeker; Maya A Ramrattan; Jordy J S Kiewiet; Marcel G W Dijkgraaf; Marja A Boermeester; Loraine Lie-A-Huen Journal: Int J Clin Pharm Date: 2013-05-31
Authors: David C Evans; Anthony T Gerlach; Jonathan M Christy; Amy M Jarvis; David E Lindsey; Melissa L Whitmill; Daniel Eiferman; Claire V Murphy; Charles H Cook; Paul R Beery; Steven M Steinberg; Stanislaw Pa Stawicki Journal: Int J Crit Illn Inj Sci Date: 2011-07
Authors: Eveline B Boeker; Monica de Boer; Jordy J S Kiewiet; Loraine Lie-A-Huen; Marcel G W Dijkgraaf; Marja A Boermeester Journal: BMC Health Serv Res Date: 2013-09-28 Impact factor: 2.655
Authors: Stanislaw P Stawicki; Sarathi Kalra; Christian Jones; Carla F Justiniano; Thomas J Papadimos; Sagar C Galwankar; Scott M Pappada; John J Feeney; David C Evans Journal: J Emerg Trauma Shock Date: 2015 Oct-Dec