| Literature DB >> 12578725 |
W G Austen1, L Kobzik, M C Carroll, H B Hechtman, F D Moore.
Abstract
Activation of the complement cascade is central to many types of injury. Ischemia-reperfusion is an important example of such an event. Using intestinal ischemia-reperfusion as a model, we have further elucidated the importance and mechanism of this activation. Of novel importance is the evidence that natural antibody is a trigger for these events via recognition of self-antigen. In this article, we review the role of natural antibody and complement in intestinal ischemia-reperfusion injury. It is hoped that this study will ultimately lead to better understanding of these important modulators and their role in this type of injury.Entities:
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Year: 2003 PMID： 12578725 DOI： 10.1177/039463200301600101
Source DB: PubMed Journal: Int J Immunopathol Pharmacol ISSN： 0394-6320 Impact factor: 3.219