Literature DB >> 1257774

Hyperphagia and increased growth in rats after intraventricular injection of 5,7-dihydroxytryptamine.

C F Saller, E M Stricker.   

Abstract

Juvenile male rats given intracerebroventricular injections of 5,7-dihydroxytryptamine, following treatment with desmethylimipramine, maintained body weight gains of 5 to 6 grams per day into adulthood and grew much larger than control rats. Biochemical analyses of brain tissue obtained 50 to 140 days after the injections revealed 60 to 86% depletions of telencephalic 5-hydroxytryptamine, with catecholamine levels unchanged. Hyperphagia did not develop despite comparable losses of 5-hydroxytryptamine when the pretreatment was withheld, perhaps because substantial depletions of norepinephrine occurred as well.

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Year:  1976        PMID： 1257774     DOI： 10.1126/science.1257774

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  33 in total

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Review 4.  Central nervous control of energy and glucose balance: focus on the central melanocortin system.

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Review 5.  Synaptic and extrasynaptic secretion of serotonin.

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9.  Serotonin 5-HT2C receptor agonist promotes hypophagia via downstream activation of melanocortin 4 receptors.

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Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530
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