Prenatal diagnosis of a large centromeric heteromorphism of chromosome 12: implications for genetic counseling.

Chromosomal centromeric variants can be found in the course of a prenatal diagnosis. When following the discovery of fetal abnormalities at ultrasound examination, such variants may lead to some difficulties in genetic counseling. Here we describe a new heteromorphism implicating chromosome 12, found in a fetus with a suspicion of microcephaly, and we discuss its prognostic value. Copyright 2003 S. Karger AG, Basel