| Literature DB >> 12576663 |
Takashi Yanagi1, Ken Kikuchi, Hideki Takeuchi, Takehiro Ishikawa, Toshihiro Nishimura, Minoru Kubota, Iwao Yamamoto.
Abstract
Chiral bis(alpha, alpha-diphenyl-2-pyrrolidinemethanol) carbonate (DPP(2).H(2)CO(3)) is a useful asymmetric auxiliary for the asymmetric borane reduction of prochiral ketones. Chiral DPP(2).H(2)CO(3) is recoverable from the reaction and directly reusable for the reaction. The intermediate of KUR-1246, which we are developing as a new uterine relaxant, was synthesized using the methodology.Entities:
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Year: 2003 PMID： 12576663 DOI： 10.1248/cpb.51.221
Source DB: PubMed Journal: Chem Pharm Bull (Tokyo) ISSN： 0009-2363 Impact factor: 1.645