| Literature DB >> 1257604 |
J G Wagner, D J Weidler, Y J Lin.
Abstract
A novel method for detecting and quantitating pharmacokinetic drug-drug interactions is described. The method involves perturbation of an existing steady-state whole blood (or plasma) concentration of one drug by the other drug. The method would allow differentiation of "pharmacokinetic" drug interactions from "pharmacologic" interactions. It is shown that a bolus intravenous injection of propranolol reduced a steady-state arterial blood concentration of ethyl alcohol by 26% in the cat.Entities:
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Year: 1976 PMID： 1257604
Source DB: PubMed Journal: Res Commun Chem Pathol Pharmacol ISSN： 0034-5164