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Literature DB >> 12575947

Synaptic ribbon. Conveyor belt or safety belt?

Abstract

The synaptic ribbon in neurons that release transmitter via graded potentials has been considered as a conveyor belt that actively moves vesicles toward their release sites. But evidence has accumulated to the contrary, and it now seems plausible that the ribbon serves instead as a safety belt to tether vesicles stably in mutual contact and thus facilitate multivesicular release by compound exocytosis.

Mesh：

Year: 2003 PMID： 12575947 DOI： 10.1016/s0896-6273(03)00062-x

Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173

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Cited

60 in total

1. Synaptic cleft acidification and modulation of short-term depression by exocytosed protons in retinal bipolar cells.

Authors: Mary J Palmer; Court Hull; Jozsef Vigh; Henrique von Gersdorff
Journal: J Neurosci Date: 2003-12-10 Impact factor: 6.167

2. Evidence that fast exocytosis can be predominantly mediated by vesicles not docked at active zones in frog saccular hair cells.

Authors: Brian W Edmonds; Frederick D Gregory; Felix E Schweizer
Journal: J Physiol Date: 2004-08-12 Impact factor: 5.182

3. Ca(2+) influx and neurotransmitter release at ribbon synapses.

Authors: Soyoun Cho; Henrique von Gersdorff
Journal: Cell Calcium Date: 2012-07-08 Impact factor: 6.817

4. Two modes of release shape the postsynaptic response at the inner hair cell ribbon synapse.

Authors: Lisa Grant; Eunyoung Yi; Elisabeth Glowatzki
Journal: J Neurosci Date: 2010-03-24 Impact factor: 6.167

5. Increase in efficiency and reduction in Ca2+ dependence of exocytosis during development of mouse inner hair cells.

Authors: Stuart L Johnson; Walter Marcotti; Corné J Kros
Journal: J Physiol Date: 2004-12-21 Impact factor: 5.182

6. Evidence that rapid vesicle replenishment of the synaptic ribbon mediates recovery from short-term adaptation at the hair cell afferent synapse.

Authors: Maria A Spassova; Michael Avissar; Adam C Furman; Mark A Crumling; James C Saunders; Thomas D Parsons
Journal: J Assoc Res Otolaryngol Date: 2004-12

Synaptic ribbon. Conveyor belt or safety belt?

1. Synaptic cleft acidification and modulation of short-term depression by exocytosed protons in retinal bipolar cells.

2. Evidence that fast exocytosis can be predominantly mediated by vesicles not docked at active zones in frog saccular hair cells.

3. Ca(2+) influx and neurotransmitter release at ribbon synapses.

4. Two modes of release shape the postsynaptic response at the inner hair cell ribbon synapse.

5. Increase in efficiency and reduction in Ca2+ dependence of exocytosis during development of mouse inner hair cells.

6. Evidence that rapid vesicle replenishment of the synaptic ribbon mediates recovery from short-term adaptation at the hair cell afferent synapse.

Review 7. Time and intensity coding at the hair cell's ribbon synapse.

8. Roles of cell-intrinsic and microenvironmental factors in photoreceptor cell differentiation.

9. A clockwork hypothesis: synaptic release by rod photoreceptors must be regular.

Review 10. Synaptic transmission at retinal ribbon synapses.