[Experimental pharmacodynamic study on the anti-convulsion effect of shenpu decoction].

OBJECTIVE: To observe the anti-convulsion effect of Shenpu Decoction (SPD).
METHODS: Experiments were conducted in three acute convulsion models (cardiazol seizure, strychnine convulsion and maximal electrical shock). Models were divided into the control group (A, treated by normal saline), the high, middle and low dose SPD groups (B, C and D, treated with SPD 9 g/kg, 6 g/kg and 4 g/kg respectively), and the nitrazepam treated group (E). The anti-convulsion effect of SPD was evaluated by 50% convulsion dose (CD50) detected in each group.
RESULTS: In cardiazol convulsion model, the CD50 detected in group A-E were 63.3 +/- 3.4 mg/kg, 116.2 +/- 3.4 mg/kg, 105.6 +/- 3.7 mg/kg, 74.0 +/- 3.7 mg/kg and 197.2 +/- 3.3 mg/kg respectively, while they were 0.71 +/- 0.04 mg/kg, 1.21 +/- 0.04 mg/kg, 1.19 +/- 0.04 mg/kg, 0.94 +/- 0.04 mg/kg and 1.16 +/- 0.04 mg/kg respectively in the strychnine convulsion model, and 67.1 +/- 2.6 V, > 140 V, 109.4 +/- 3.5 V, 84.4 +/- 3.1 V and 128.4 +/- 3.9 V in the maximal electrical shock model respectively.
CONCLUSION: SPD has a good anticonvulsion effect.