BACKGROUND: Aphthous ulcers are an extremely common disorder of unknown etiology. These ulcers cause significant morbidity through pain and interference with eating. Thalidomide, an angiogenesis inhibitor, is efficacious for the treatment of aphthous ulcers. METHODS: In situ hybridization was performed on an idiopathic aphthous ulcer using probes specific for the angiogenesis factor vascular endothelial growth factor, and its receptors, in order to determine whether these ulcers are highly angiogenic. CONCLUSIONS: Aphthous ulcers are highly angiogenic. Thalidomide may act to heal aphthous ulcers by inhibiting angiogenesis and promoting reepithelialization. Excess angiogenesis may inhibit reepithelialization in certain types of ulcers, and angiogenesis inhibitors may actually promote wound healing if ulcers are caused by excess angiogenesis.
BACKGROUND:Aphthous ulcers are an extremely common disorder of unknown etiology. These ulcers cause significant morbidity through pain and interference with eating. Thalidomide, an angiogenesis inhibitor, is efficacious for the treatment of aphthous ulcers. METHODS: In situ hybridization was performed on an idiopathic aphthous ulcer using probes specific for the angiogenesis factor vascular endothelial growth factor, and its receptors, in order to determine whether these ulcers are highly angiogenic. CONCLUSIONS:Aphthous ulcers are highly angiogenic. Thalidomide may act to heal aphthous ulcers by inhibiting angiogenesis and promoting reepithelialization. Excess angiogenesis may inhibit reepithelialization in certain types of ulcers, and angiogenesis inhibitors may actually promote wound healing if ulcers are caused by excess angiogenesis.
Authors: Adrià Aterido; Antonio Julià; Patricia Carreira; Ricardo Blanco; José Javier López-Longo; José Javier Pérez Venegas; Àlex Olivé; José Luís Andreu; Maria Ángeles Aguirre-Zamorano; Paloma Vela; Joan M Nolla; José Luís Marenco-de la Fuente; Antonio Zea; José María Pego; Mercedes Freire; Elvira Díez; María López-Lasanta; Mireia López-Corbeto; Núria Palau; Raül Tortosa; Josep Lluís Gelpí; Devin Absher; Richard M Myers; Antonio Fernández-Nebro; Sara Marsal Journal: Arthritis Res Ther Date: 2017-06-15 Impact factor: 5.156
Authors: Thiago A F Ferro; Eliene B Souza; Mariela A M Suarez; João F S Rodrigues; Domingos M S Pereira; Saulo J F Mendes; Laoane F Gonzaga; Márcia C A M Machado; Maria R Q Bomfim; João B Calixto; Jack L Arbiser; Valério Monteiro-Neto; Eunice André; Elizabeth S Fernandes Journal: Molecules Date: 2019-04-25 Impact factor: 4.411