Literature DB >> 1257370

Effect of cannabinoids on the abdominal constriction response in mice: within cannabinoid interactions.

P J Welburn, G A Starmer, G B Chesher, D M Jackson.   

Abstract

After oral administration to mice, delta9-tetrahydrocannabinol (THC) and cannabinol (CBN) caused a dose-dependent suppression of the abdominal constriction response to formic acid. Cannabinol was 50 times less active than THC and cannabidiol (CBD) was without effect. The effects of THC and CBN were additive. CBD antagonised the antinociceptive effects of both THC and CBN in a dose-dependent manner.

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Year:  1976        PMID： 1257370     DOI： 10.1007/BF00421553

Source DB:  PubMed          Journal:  Psychopharmacologia


  21 in total

1.  THE USE OF CHANGES IN CAPILLARY PERMEABILITY IN MICE TO DISTINGUISH BETWEEN NARCOTIC AND NONNARCOTIC ALALGESICS.

Authors:  B A WHITTLE
Journal:  Br J Pharmacol Chemother       Date:  1964-04

2.  PHENYLQUINONE WRITHING TEST: INTERPRETATION OF DATA.

Authors:  R T BRITTAIN; D N LEHRER; P S SPENCER
Journal:  Nature       Date:  1963-11-30       Impact factor: 49.962

3.  RELEASE OF A KININ BY INTRAPERITONEAL INJECTION OF CHEMICAL AGENTS IN MICE.

Authors:  B A WHITTLE
Journal:  Int J Neuropharmacol       Date:  1964-09

4.  Pharmacologic interaction between cannabinol and delta9-tetrahydrocannabinol.

Authors:  R N Takahashi; I G Karniol
Journal:  Psychopharmacologia       Date:  1975

5.  Conditions influencing the inhibition, by analgesic drugs, of the response to intraperitoneal injections of phenylbenzoquinone in mice.

Authors:  M W Parkes; J T Pickens
Journal:  Br J Pharmacol Chemother       Date:  1965-08

6.  The abdominal constriction response and its suppression by analgesic drugs in the mouse.

Authors:  H O Collier; L C Dinneen; C A Johnson; C Schneider
Journal:  Br J Pharmacol Chemother       Date:  1968-02

7.  Prostaglandins and cannabis. II. Inhibition of biosynthesis by the naturally occurring cannabinoids.

Authors:  S Burstein; E Levin; C Varanelli
Journal:  Biochem Pharmacol       Date:  1973-11-15       Impact factor: 5.858

8.  Interaction of delta9-tetrahydrocannabinol and cannabidiol on intestinal motility in mice.

Authors:  P F Anderson; D M Jackson; G B Chesher
Journal:  J Pharm Pharmacol       Date:  1974-02       Impact factor: 3.765

9.  Comparative analgesic activity of various naturally occurring cannabinoids in mice and rats.

Authors:  R D Sofia; H B Vassar; L C Knobloch
Journal:  Psychopharmacologia       Date:  1975

10.  Interaction of cannabis and general anaesthetic agents in mice.

Authors:  G B Chesher; D M Jackson; G A Starmer
Journal:  Br J Pharmacol       Date:  1974-04       Impact factor: 8.739
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  10 in total

1.  Chromenopyrazoles: non-psychoactive and selective CB₁ cannabinoid agonists with peripheral antinociceptive properties.

Authors:  Jose Cumella; Laura Hernández-Folgado; Rocio Girón; Eva Sánchez; Paula Morales; Dow P Hurst; Maria Gómez-Cañas; Maria Gómez-Ruiz; Diana C G A Pinto; Pilar Goya; Patricia H Reggio; María Isabel Martin; Javier Fernández-Ruiz; Artur M S Silva; Nadine Jagerovic
Journal:  ChemMedChem       Date:  2012-02-02       Impact factor: 3.466

2.  Interactions between THC and cannabidiol in mouse models of cannabinoid activity.

Authors:  S A Varvel; J L Wiley; R Yang; D T Bridgen; K Long; A H Lichtman; B R Martin
Journal:  Psychopharmacology (Berl)       Date:  2006-03-30       Impact factor: 4.530

3.  The effect of cannabidiol, alone and in combination with ethanol, on human performance.

Authors:  B E Belgrave; K D Bird; G B Chesher; D M Jackson; K E Lubbe; G A Starmer; R K Teo
Journal:  Psychopharmacology (Berl)       Date:  1979-08-08       Impact factor: 4.530

4.  Single and combined effects of Δ9 -tetrahydrocannabinol and cannabidiol in a mouse model of chemotherapy-induced neuropathic pain.

Authors:  Kirsten M King; Alyssa M Myers; Ariele J Soroka-Monzo; Ronald F Tuma; Ronald J Tallarida; Ellen A Walker; Sara Jane Ward
Journal:  Br J Pharmacol       Date:  2017-07-27       Impact factor: 8.739

5.  Divergent effects of cannabidiol on the discriminative stimulus and place conditioning effects of Delta(9)-tetrahydrocannabinol.

Authors:  Robert E Vann; Thomas F Gamage; Jonathan A Warner; Ericka M Marshall; Nathan L Taylor; Billy R Martin; Jenny L Wiley
Journal:  Drug Alcohol Depend       Date:  2008-04-01       Impact factor: 4.492

6.  Interactions among the cannabinoids in the antagonism of the abdominal constriction response in the mouse.

Authors:  J Sanders; D M Jackson; G A Starmer
Journal:  Psychopharmacology (Berl)       Date:  1979-03-28       Impact factor: 4.530

7.  The interaction between prostaglandin E1 and delta 9-tetrahydrocannabinol on intestinal motility and on the abdominal constriction response in the mouse.

Authors:  D M Jackson; R Malor; G B Chesher; G A Starmer; P J Welburn; R Bailey
Journal:  Psychopharmacologia       Date:  1976-05-28

8.  The effect of delta 9-tetrahydrocannabinol, cannabidiol, and cannabinol on the anaesthesia induced by various anaesthetic agents in mice.

Authors:  J Frizza; G B Chesher; D M Jackson; R Malor; G A Starmer
Journal:  Psychopharmacology (Berl)       Date:  1977-11-24       Impact factor: 4.530

9.  Evaluation of prevalent phytocannabinoids in the acetic acid model of visceral nociception.

Authors:  Lamont Booker; Pattipati S Naidu; Raj K Razdan; Anu Mahadevan; Aron H Lichtman
Journal:  Drug Alcohol Depend       Date:  2009-08-12       Impact factor: 4.492

10.  Cannabidiol in humans-the quest for therapeutic targets.

Authors:  Simon Zhornitsky; Stéphane Potvin
Journal:  Pharmaceuticals (Basel)       Date:  2012-05-21
  10 in total

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