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Literature DB >> 1257367

Autoradiographic studies on the distribution of 3H-2,3,4-trimethoxy-beta-phenylethylamine in the mouse.

Abstract

The regional distribution of radioactivity was studied in the brain and in other organs of the mouse by light microscopic autoradiography after injection of 3H-2,3,4-trimethoxy-beta-phenylethylamine (2,3,4,-TMPEA), a nonhallucinogenic isomer of mescaline. The distribution patterns were compared with biochemical and autoradiographic results obtained after 3H-mescaline. Although 2,3,4-TMPEA is rapidly deaminated compared to mescaline its distribution pattern in the brain is similar to that of mescaline at 1 h after injection. However, contrary to mescaline the radioactive labeling becomes more and more homogenously distributed in the brain with tiem. The distribution patterns in kidney, pancreas, adrenal, and spinal ganglia were also different from those observed after application of 3H-mescaline.

Entities: Chemical Disease Species

Mesh：

Substances：
Mescaline

Year: 1976 PMID： 1257367 DOI： 10.1007/BF00421549

Source DB: PubMed Journal: Psychopharmacologia

19 in total

1. Distribution of carbon-14 labeled isoniazid in brain.

Authors: C F BARLOW; J C SCHOOLAR; L J ROTH
Journal: Neurology Date: 1957-12 Impact factor: 9.910

2. [Autoradiographic studies on the distribution of the thioxanthene derivative 14C-BP 400 in the rat brain].

Authors: H Eckert; A Hopf
Journal: Arzneimittelforschung Date: 1970-11

3. Oxidative metabolism of mescaline in the central nervous system. 3. Side chain degradation of mescaline and formation of 3,4,5-trimethoxy-benzoic acid in vivo.

Authors: N Seiler; L Demisch
Journal: Biochem Pharmacol Date: 1974-01-15 Impact factor: 5.858

4. Oxidative metabolism of mescaline in the central nervous system. IV. In vivo metabolism of mescaline and 2,3,4-trimethoxy-beta-phenylethylamine.

Authors: N Seiler; L Demisch
Journal: Biochem Pharmacol Date: 1974-01-15 Impact factor: 5.858

5. Oxidative metabolism of mescaline in the central nervous system. II. Oxidative deamination of mescaline and 2,3,4-trimethoxy-beta-phenylethylamine by different mouse brain area in vitro.

Authors: N Seiler; L Demisch
Journal: Biochem Pharmacol Date: 1971-09 Impact factor: 5.858

Autoradiographic studies on the distribution of 3H-2,3,4-trimethoxy-beta-phenylethylamine in the mouse.

1. Distribution of carbon-14 labeled isoniazid in brain.

2. [Autoradiographic studies on the distribution of the thioxanthene derivative 14C-BP 400 in the rat brain].

3. Oxidative metabolism of mescaline in the central nervous system. 3. Side chain degradation of mescaline and formation of 3,4,5-trimethoxy-benzoic acid in vivo.

4. Oxidative metabolism of mescaline in the central nervous system. IV. In vivo metabolism of mescaline and 2,3,4-trimethoxy-beta-phenylethylamine.

5. Oxidative metabolism of mescaline in the central nervous system. II. Oxidative deamination of mescaline and 2,3,4-trimethoxy-beta-phenylethylamine by different mouse brain area in vitro.

6. Autoradiographic studies on the distribution of psychoactive drugs in the rat brain. 3. 14C-psilocin.

7. [Autoradiography studies on the distribution of mescaline and its influence on the central excitation of mice].

8. [Cholesterol-crystal deposition in frozen sections of nervous tissue as a cause of artefacts in autoradiograms].

9. A relationship between the hallucinogenic activity of drugs and their electronic configuration.

10. Steric and electronic relationships among some hallucinogenic compounds.

1. Autoradiographic studies on the distribution of 3H-mescaline in the brain of the marmoset, Callithrix jacchus.

Review 2. Molecular and Functional Imaging Studies of Psychedelic Drug Action in Animals and Humans.