Literature DB >> 12573482

Functional and structural comparison of PXR and CAR.

John T Moore1, Linda B Moore, Jodi M Maglich, Steve A Kliewer.   

Abstract

The nuclear receptors pregnane X receptor (PXR, NR1I2) and constitutive active receptor (CAR, NR1I3) have both been proposed to function as xenosensors, but the details of their respective physiological roles are still being elucidated. We have contrasted these two receptors in a variety of experiments including gene expression assays, cell-based ligand profiling assays, and crystallographic/structural modeling analyses. These data highlight key differences between PXR and CAR.

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Year:  2003        PMID： 12573482     DOI： 10.1016/s0304-4165(02)00481-6

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  27 in total

1.  Molecular dynamics simulations of the human CAR ligand-binding domain: deciphering the molecular basis for constitutive activity.

Authors:  Björn Windshügel; Johanna Jyrkkärinne; Antti Poso; Paavo Honkakoski; Wolfgang Sippl
Journal:  J Mol Model       Date:  2004-12-23       Impact factor: 1.810

2.  Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation.

Authors:  J P Hernandez; L C Mota; W S Baldwin
Journal:  Curr Pharmacogenomics Person Med       Date:  2009-06-01

3.  Relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (POR) null mice.

Authors:  Xiu Jun Wang; Mark Chamberlain; Olga Vassieva; Colin J Henderson; C Roland Wolf
Journal:  Biochem J       Date:  2005-06-15       Impact factor: 3.857

4.  Pharmacological Activation of PXR and CAR Downregulates Distinct Bile Acid-Metabolizing Intestinal Bacteria and Alters Bile Acid Homeostasis.

Authors:  Joseph L Dempsey; Dongfang Wang; Gunseli Siginir; Qiang Fei; Daniel Raftery; Haiwei Gu; Julia Yue Cui
Journal:  Toxicol Sci       Date:  2019-03-01       Impact factor: 4.849

5.  Studies on induction of lamotrigine metabolism in transgenic UGT1 mice.

Authors:  U A Argikar; K Senekeo-Effenberger; E E Larson; R H Tukey; R P Remmel
Journal:  Xenobiotica       Date:  2009-11       Impact factor: 1.908

6.  Functional characterization of a full length pregnane X receptor, expression in vivo, and identification of PXR alleles, in zebrafish (Danio rerio).

Authors:  Afonso C D Bainy; Akira Kubota; Jared V Goldstone; Roger Lille-Langøy; Sibel I Karchner; Malin C Celander; Mark E Hahn; Anders Goksøyr; John J Stegeman
Journal:  Aquat Toxicol       Date:  2013-09-20       Impact factor: 4.964

7.  Impact of Drug Treatment at Neonatal Ages on Variability of Drug Metabolism and Drug-drug Interactions in Adult Life.

Authors:  Stephanie Piekos; Chad Pope; Austin Ferrara; Xiao-Bo Zhong
Journal:  Curr Pharmacol Rep       Date:  2017-01-03

8.  Editor's Highlight: Neonatal Activation of the Xenobiotic-Sensors PXR and CAR Results in Acute and Persistent Down-regulation of PPARα-Signaling in Mouse Liver.

Authors:  Cindy Yanfei Li; Sunny Lihua Cheng; Theo K Bammler; Julia Yue Cui
Journal:  Toxicol Sci       Date:  2016-07-13       Impact factor: 4.849

Review 9.  Human relevance of rodent liver tumour formation by constitutive androstane receptor (CAR) activators.

Authors:  Brian G Lake
Journal:  Toxicol Res (Camb)       Date:  2018-03-12       Impact factor: 3.524

10.  Activating PKC-β1 at the blood-brain barrier reverses induction of P-glycoprotein activity by dioxin and restores drug delivery to the CNS.

Authors:  Xueqian Wang; Brian T Hawkins; David S Miller
Journal:  J Cereb Blood Flow Metab       Date:  2011-04-13       Impact factor: 6.200
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