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Literature DB >> 12572875

DNA methylation changes in gastrointestinal disease.

Minoru Toyota¹, Fumio Itoh, Takefumi Kikuchi, Ayumi Satoh, Toshiro Obata, Hiromu Suzuki, Suguru Ishii, Takao Endo, Takashi Tokino, Kohzoh Imai.

Abstract

DNA methylation of the 5' region of genes is often associated with gene silencing in X-chromosome inactivation and imprinting. Recent studies have indicated that altered DNA methylation plays a role in the inactivation of multiple tumor suppressor genes and DNA repair genes such as p16INK4A and hMLH1. Colorectal adenomas have a relatively high frequency of methylation, and aberrant methylation is an early event during tumorigenesis. In aging patients, even colon epithelium which appears to be normal showed a significant amount of methylation in a subset of the genes. Colon mucosa from patients with inflammatory bowel disease also showed a high level of methylation. DNA methylation can be a specific diagnostic marker in gastrointestinal cancer and inflammatory bowel disease, for which there is no perfect marker for a noninvasive diagnosis.

Entities: Disease Gene Species

Mesh：

Year: 2002 PMID： 12572875 DOI： 10.1007/BF03326425

Source DB: PubMed Journal: J Gastroenterol ISSN： 0944-1174 Impact factor: 7.527

32 in total

Review 1. Influence of oxygen radical injury on DNA methylation.

Authors: S Cerda; S A Weitzman
Journal: Mutat Res Date: 1997-04 Impact factor: 2.433

2. Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status.

Authors: M Esteller; S Tortola; M Toyota; G Capella; M A Peinado; S B Baylin; J G Herman
Journal: Cancer Res Date: 2000-01-01 Impact factor: 12.701

3. High incidence of allelic loss on chromosome 5 and inactivation of p15INK4B and p16INK4A tumor suppressor genes in oxystress-induced renal cell carcinoma of rats.

Authors: T Tanaka; Y Iwasa; S Kondo; H Hiai; S Toyokuni
Journal: Oncogene Date: 1999-06-24 Impact factor: 9.867

DNA methylation changes in gastrointestinal disease.

Review 1. Influence of oxygen radical injury on DNA methylation.

2. Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status.

3. High incidence of allelic loss on chromosome 5 and inactivation of p15INK4B and p16INK4A tumor suppressor genes in oxystress-induced renal cell carcinoma of rats.

4. Mutations in the p53 gene: an early marker of neoplastic progression in ulcerative colitis.

Review 5. Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer.

6. Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype.

7. CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression.

8. CpG island methylator phenotype in colorectal cancer.

9. DNA methylation and genetic instability in colorectal cancer cells.

10. Hypermethylation of multiple genes in pancreatic adenocarcinoma.

1. Identification of disease-associated DNA methylation in B cells from Crohn's disease and ulcerative colitis patients.

2. Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma.

3. DNA methylation profile of genes involved in inflammation and autoimmunity in inflammatory bowel disease.

4. Genome-wide DNA Methylation in Treatment-naïve Ulcerative Colitis.