| Literature DB >> 1257249 |
D M Gross, V M Mujovic, W Jubiz, J W Fisher.
Abstract
Renal artery constriction (RAC) to 30% of normal flow for 12 hr in the unilaterally nephrectomized dog produced a marked increase in both erythropoietin titers and prostaglandin E (PGE) levels in the blood. In dogs pretreated prior to RAC with indomethacin, a potent inhibitor of prostaglandin synthetase, there was no significant increase in either PGE or erythropoietin levels as compared to zero-time control values. These data suggested an involvement of renal PGE in the generation of erythropoietin following RAC.Entities:
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Year: 1976 PMID： 1257249 DOI： 10.3181/00379727-151-39244
Source DB: PubMed Journal: Proc Soc Exp Biol Med ISSN： 0037-9727