Literature DB >> 12570755

Medicinal chemistry of adenosine A1 receptor ligands.

Willem Soudijn1, Ineke van Wijngaarden, Ad P IJzerman.   

Abstract

In this review the latest developments in ligand design for the adenosine A(1) receptor are summarized. Novel series of agonists and antagonists are discussed, leading to the conclusion that ligands truly selective for the human adenosine A(1) receptor are still scarce.

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Year:  2003        PMID： 12570755     DOI： 10.2174/1568026033392165

Source DB:  PubMed          Journal:  Curr Top Med Chem        ISSN： 1568-0266            Impact factor:   3.295


  4 in total

1.  Allosteric modulation, thermodynamics and binding to wild-type and mutant (T277A) adenosine A1 receptors of LUF5831, a novel nonadenosine-like agonist.

Authors:  Laura H Heitman; Thea Mulder-Krieger; Ronald F Spanjersberg; Jacobien K von Frijtag Drabbe Künzel; Alessandro Dalpiaz; Adriaan P IJzerman
Journal:  Br J Pharmacol       Date:  2006-03       Impact factor: 8.739

2.  Inhibitors of membranous adenylyl cyclases with affinity for adenosine receptors.

Authors:  Karl-Norbert Klotz; Sonja Kachler
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2015-12-14       Impact factor: 3.000

Review 3.  Progress in the pursuit of therapeutic adenosine receptor antagonists.

Authors:  Stefano Moro; Zhan-Guo Gao; Kenneth A Jacobson; Giampiero Spalluto
Journal:  Med Res Rev       Date:  2006-03       Impact factor: 12.388

4.  Ribose and Non-Ribose A2A Adenosine Receptor Agonists: Do They Share the Same Receptor Recognition Mechanism?

Authors:  Giovanni Bolcato; Matteo Pavan; Davide Bassani; Mattia Sturlese; Stefano Moro
Journal:  Biomedicines       Date:  2022-02-21
  4 in total

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