| Literature DB >> 12570385 |
Nobutoshi Murakami1, Masanori Sugimoto, Motoyuki Kawanishi, Satoru Tamura, Hye-Sook Kim, Khurshida Begum, Yusuke Wataya, Motomasa Kobayashi.
Abstract
On the basis of a comparative analysis for stability in mouse serum between 15-O-acetylbruceolide and bruceolide 15-methyl carbonate, several 3,15-dialkyl carbonates of bruceolide were synthesized and their in vitro antimalarial activity was assessed. Methyl, ethyl, and isopropyl carbonates with pronounced in vitro activity were further evaluated for in vivo antimalarial potency. Both the methyl and ethyl carbonates significantly increased the life span of mice as compared with 3,15-di-O-accetylbruceolide and chloroquine.Entities:
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Year: 2003 PMID： 12570385 DOI： 10.1021/jm0201971
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446