Literature DB >> 12568349

Synthesis and antiinflammatory activity of novel indazolones.

Khaled A M Abouzid1, H S el-Abhar.   

Abstract

In this study, a series of new N2 substituted 1,2-dihydro-3H-indazol-3-ones (3a-d) as well as their condensed pyrazolo, pyridazino derivatives such as pyridazino[1,2-a]indazole-6,9,11-triones (4a-h) and 3,9-dioxo-3H,9H-pyrazolo[1,2-a]indazole (7) were synthesized. The antiinflammatory activity of some synthesized compounds was determined by carrageenan-induced rat paw edema technique using diclofenac as reference drug. The pharmacological data showed that most of the tested compounds exhibited a significant long lasting antiinflammatory activity, which in the case of compound 3b was superior to that of diclofenac.

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Year:  2003        PMID： 12568349     DOI： 10.1007/BF03179922

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  7 in total

1.  Nucleophilic substitution of oxazino-/oxazolino-/benzoxazin [3,2-b]indazoles: an effective route to 1H-indazolones.

Authors:  Michael B Donald; Wayne E Conrad; James S Oakdale; Jeffrey D Butler; Makhluf J Haddadin; Mark J Kurth
Journal:  Org Lett       Date:  2010-06-04       Impact factor: 6.005

2.  Efficient synthesis of highly substituted tetrahydroindazolone derivatives.

Authors:  Angela Scala; Anna Piperno; Francesco Risitano; Santa Cirmi; Michele Navarra; Giovanni Grassi
Journal:  Mol Divers       Date:  2015-03-18       Impact factor: 2.943

3.  A one-pot-three-step route to triazolotriazepinoindazolones from oxazolino-2H-indazoles.

Authors:  Wayne E Conrad; Kevin X Rodriguez; Huy H Nguyen; James C Fettinger; Makhluf J Haddadin; Mark J Kurth
Journal:  Org Lett       Date:  2012-07-23       Impact factor: 6.005

4.  Electrochemical synthesis of N,N'-disubstituted indazolin-3-ones via an intramolecular anodic dehydrogenative N-N coupling reaction.

Authors:  Jessica C Bieniek; Michele Grünewald; Johannes Winter; Dieter Schollmeyer; Siegfried R Waldvogel
Journal:  Chem Sci       Date:  2022-06-13       Impact factor: 9.969

5.  A novel indazolo-triazolo-benzotriazepine exerts anti-inflammatory effects by inhibition of cyclooxygenase-2 activity and nitric oxide synthase-2 expression.

Authors:  Patricia Fernández; M Isabel Guillén; Amalia Ubeda; Pablo López-Cremades; Enrique Aller; Angeles Lorenzo; Pedro Molina; M José Alcaraz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-06-24       Impact factor: 3.000

6.  Rapid and halide compatible synthesis of 2-N-substituted indazolone derivatives via photochemical cyclization in aqueous media.

Authors:  Hui-Jun Nie; An-Di Guo; Hai-Xia Lin; Xiao-Hua Chen
Journal:  RSC Adv       Date:  2019-04-30       Impact factor: 4.036

7.  Regioselective SN2' Mitsunobu reaction of Morita-Baylis-Hillman alcohols: A facile and stereoselective synthesis of α-alkylidene-β-hydrazino acid derivatives.

Authors:  Silong Xu; Jian Shang; Junjie Zhang; Yuhai Tang
Journal:  Beilstein J Org Chem       Date:  2014-04-30       Impact factor: 2.883
  7 in total

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