| Literature DB >> 12567293 |
Ahmed Abbaskhan, M Iqbal Choudhary, Yoshisuke Tsuda, Masood Parvez, Farzana Shaheen, Zeba Parween, Rasool Baksh Tareen, Mudassir Asrar Zaidi.
Abstract
A new diterpenoid, rugosinin (1), isolated from Isodon rugosus, with absolute configuration was proved by single-crystal X-ray diffraction analysis, to be the member of a rare class of C-20/C-7 and C-20/C-14 diepoxy- ent-kauranoids. Effusanin A (2), effusanin B (3), effusanin E (4), lasiokaurin (5) and oridonin (6) were found as known constituents of the genus Isodon with C-20/C-7 epoxy function. These compounds have exhibited DNA-damaging activity in assay which employed DNA-repair deficient (RAD 52Y) and repair proficient (RAD +) yeast strains.Entities:
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Year: 2003 PMID： 12567293 DOI： 10.1055/s-2003-37031
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352