| Literature DB >> 12566927 |
Abstract
Accumulating evidence indicates that serine/threonine (Ser/Thr) protein phosphatases (PPs), such as PP1, PP2A and PP2B, participate in the neurodegenerative progress in Alzheimer's disease (AD). The general characteristics and pathologic changes of PP1, PP2A and PP2B in AD, and their relations with microtubule-associated proteins, focusing mainly on tau protein, neurofilament (NF), amyloid precursor protein (APP) processing and synaptic plasticity are discussed. Deriving novel insight into the particular topic will attract greater attention to more active investigation and effective therapeutic intervention in the future. Copyright 2003 S. Karger AG, BaselEntities:
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Year: 2002 PMID： 12566927 DOI： 10.1159/000067425
Source DB: PubMed Journal: Neurosignals ISSN： 1424-862X