Literature DB >> 12565975

Selective phenolic acylation of 10-hydroxycamptothecin using poly (ethylene glycol) carboxylic acid.

Richard B Greenwald1, Yun H Choe, Dechun Wu.   

Abstract

Selective acylation of the phenolic hydroxyl group of 10-hydroxycamptothecin has been accomplished using phenyl dichlorophosphate. Additional modification of the 10-OH as an ether permits a 20-acyl derivative to be synthesized. This result along with data from a 6-hydroxyquinoline model strongly suggests that powerful intermolecular hydrogen bonding exists in the parent molecule.

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Year:  2003        PMID： 12565975     DOI： 10.1016/s0960-894x(02)00926-5

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Stabilization of resveratrol in blood circulation by conjugation to mPEG and mPEG-PLA polymers: investigation of conjugate linker and polymer composition on stability, metabolism, antioxidant activity and pharmacokinetic profile.

Authors:  Basavaraj Siddalingappa; Heather A E Benson; David H Brown; Kevin T Batty; Yan Chen
Journal:  PLoS One       Date:  2015-03-23       Impact factor: 3.240

2.  10-Hydroxycamptothecin (HCPT) nanosuspensions stabilized by mPEG1000-HCPT conjugate: high stabilizing efficiency and improved antitumor efficacy.

Authors:  Linjie Yang; Jingyi Hong; Jing Di; Yifei Guo; Meihua Han; Meifeng Liu; Xiangtao Wang
Journal:  Int J Nanomedicine       Date:  2017-05-12

3.  Effects of nanoparticle size on antitumor activity of 10-hydroxycamptothecin-conjugated gold nanoparticles: in vitro and in vivo studies.

Authors:  Hanmei Bao; Qing Zhang; Hui Xu; Zhao Yan
Journal:  Int J Nanomedicine       Date:  2016-03-07
  3 in total

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