Literature DB >> 12565967

Cephalosporin prodrugs of paclitaxel for immunologically specific activation by L-49-sFv-beta-lactamase fusion protein.

Vivekananda M Vrudhula1, David E Kerr, Nathan O Siemers, Gene M Dubowchik, Peter D Senter.   

Abstract

Paclitaxel conjugates of 7-phenylacetamidocephalosporanic acid were prepared as prodrugs for site specific activation by targeted beta-lactamase. Immunologically specific activation of the prodrug 5 containing 3,3-dimethyl-4-amino-butyric acid as linker in combination with the fusion protein L-49-sFv-beta-lactamase was demonstrated in vitro on 3677 melanoma cells.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 12565967     DOI： 10.1016/s0960-894x(02)00935-6

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Novel beta-lactamase-random peptide fusion libraries for phage display selection of cancer cell-targeting agents suitable for enzyme prodrug therapy.

Authors:  Girja S Shukla; David N Krag
Journal:  J Drug Target       Date:  2010-02       Impact factor: 5.121

2.  Cancer cell-specific internalizing ligands from phage displayed beta-lactamase-peptide fusion libraries.

Authors:  Girja S Shukla; David N Krag
Journal:  Protein Eng Des Sel       Date:  2010-03-10       Impact factor: 1.650

3.  Phage-displayed combinatorial peptide libraries in fusion to beta-lactamase as reporter for an accelerated clone screening: Potential uses of selected enzyme-linked affinity reagents in downstream applications.

Authors:  Girja S Shukla; David N Krag
Journal:  Comb Chem High Throughput Screen       Date:  2010-01       Impact factor: 1.339

4.  Novel integrin-targeted binding-triggered drug delivery system for methotrexate.

Authors:  Phanidhara Kotamraj; Wade A Russu; Bhaskara Jasti; Jay Wu; Xiaoling Li
Journal:  Pharm Res       Date:  2011-06-22       Impact factor: 4.200

5.  Developing bifunctional beta-lactamase molecules with built-in target-recognizing module for prodrug therapy: identification of Enterobacter Cloacae P99 cephalosporinase loops suitable for randomization and phage-display selection.

Authors:  Girja S Shukla; David N Krag
Journal:  J Mol Recognit       Date:  2009 Nov-Dec       Impact factor: 2.137

Review 6.  Prodrug Strategies for Paclitaxel.

Authors:  Ziyuan Meng; Quanxia Lv; Jun Lu; Houzong Yao; Xiaoqing Lv; Feng Jiang; Aiping Lu; Ge Zhang
Journal:  Int J Mol Sci       Date:  2016-05-23       Impact factor: 5.923
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.