Literature DB >> 12565964

5-Azidoepibatidine: an exceptionally potent photoaffinity ligand for neuronal alpha 4 beta 2 and alpha 7 nicotinic acetylcholine receptors.

Nanjing Zhang1, Motohiro Tomizawa, John E Casida.   

Abstract

Racemic 5-azidoepibatidine [(+/-)-1] was synthesized via 5-aminoepibatidine as a candidate photoaffinity ligand with exceptionally high affinity at the mammalian neuronal nicotinic receptors (K(i) values of 0.027 nM for alpha 4 beta 2 and 9.7 nM for alpha 7) and excellent photoreactivity.

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Year:  2003        PMID： 12565964     DOI： 10.1016/s0960-894x(02)00936-8

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

Review 1.  Nicotinic agonists, antagonists, and modulators from natural sources.

Authors:  John W Daly
Journal:  Cell Mol Neurobiol       Date:  2005-06       Impact factor: 5.046

2.  Nicotinic agonist binding site mapped by methionine- and tyrosine-scanning coupled with azidochloropyridinyl photoaffinity labeling.

Authors:  Motohiro Tomizawa; Todd T Talley; John F Park; David Maltby; Katalin F Medzihradszky; Kathleen A Durkin; Jose M Cornejo-Bravo; Alma L Burlingame; John E Casida; Palmer Taylor
Journal:  J Med Chem       Date:  2009-06-25       Impact factor: 7.446

3.  Defining nicotinic agonist binding surfaces through photoaffinity labeling.

Authors:  Motohiro Tomizawa; David Maltby; Katalin F Medzihradszky; Nanjing Zhang; Kathleen A Durkin; Jack Presley; Todd T Talley; Palmer Taylor; Alma L Burlingame; John E Casida
Journal:  Biochemistry       Date:  2007-07-06       Impact factor: 3.162

Review 4.  Systemic insecticides (neonicotinoids and fipronil): trends, uses, mode of action and metabolites.

Authors:  N Simon-Delso; V Amaral-Rogers; L P Belzunces; J M Bonmatin; M Chagnon; C Downs; L Furlan; D W Gibbons; C Giorio; V Girolami; D Goulson; D P Kreutzweiser; C H Krupke; M Liess; E Long; M McField; P Mineau; E A D Mitchell; C A Morrissey; D A Noome; L Pisa; J Settele; J D Stark; A Tapparo; H Van Dyck; J Van Praagh; J P Van der Sluijs; P R Whitehorn; M Wiemers
Journal:  Environ Sci Pollut Res Int       Date:  2014-09-19       Impact factor: 4.223
  4 in total

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