Literature DB >> 12565955

2-Phenylspiroindenes: a novel class of selective estrogen receptor modulators (SERMs).

Timothy A Blizzard1, Jerry D Morgan, Ralph T Mosley, Elizabeth T Birzin, Katalin Frisch, Susan P Rohrer, Milton L Hammond.   

Abstract

A series of 2-phenylspiroindenes was prepared. The most active analogue (2) was found to be comparable in potency to raloxifene (1) as an estrogen receptor ligand.

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Year:  2003        PMID： 12565955     DOI： 10.1016/s0960-894x(02)00985-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Parallel synthesis of a desketoraloxifene analogue library via iodocyclization/palladium-catalyzed coupling.

Authors:  Chul-Hee Cho; Dai-Il Jung; Benjamin Neuenswander; Richard C Larock
Journal:  ACS Comb Sci       Date:  2011-07-13       Impact factor: 3.784

2.  Identification of xenoestrogens in food additives by an integrated in silico and in vitro approach.

Authors:  Alessio Amadasi; Andrea Mozzarelli; Clara Meda; Adriana Maggi; Pietro Cozzini
Journal:  Chem Res Toxicol       Date:  2009-01       Impact factor: 3.739

3.  Enantioselective Synthesis of Spiroindenes by Enol-Directed Rhodium(III)-Catalyzed C-H Functionalization and Spiroannulation.

Authors:  Suresh Reddy Chidipudi; David J Burns; Imtiaz Khan; Hon Wai Lam
Journal:  Angew Chem Int Ed Engl       Date:  2015-09-25       Impact factor: 15.336
  3 in total

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