Literature DB >> 12565945

Novel antifungal beta-amino acids: synthesis and activity against Candida albicans.

Joachim Mittendorf1, Franz Kunisch, Michael Matzke, Hans-Christian Militzer, Axel Schmidt, Wolfgang Schönfeld.   

Abstract

A series of novel beta-amino acids has been synthesized and tested for their in vitro antifungal activity against Candida albicans. A steep SAR was observed. beta-Amino acid 21 (BAY 10-8888/PLD-118) revealed the most favourable activity-tolerability profile and was selected for clinical studies as a novel antifungal for the oral treatment of yeast infections.

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Year:  2003        PMID： 12565945     DOI： 10.1016/s0960-894x(02)00958-7

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  12 in total

1.  In vitro activity and in vivo efficacy of icofungipen (PLD-118), a novel oral antifungal agent, against the pathogenic yeast Candida albicans.

Authors:  Andreja Hasenoehrl; Tatjana Galic; Gabrijela Ergovic; Natasa Marsic; Mihael Skerlev; Joachim Mittendorf; Ulrich Geschke; Axel Schmidt; Wolfgang Schoenfeld
Journal:  Antimicrob Agents Chemother       Date:  2006-09       Impact factor: 5.191

Review 2.  Catalytic asymmetric cycloaddition reactions of enoldiazo compounds.

Authors:  Kostiantyn O Marichev; Michael P Doyle
Journal:  Org Biomol Chem       Date:  2019-04-24       Impact factor: 3.876

3.  Recent Advances in the Synthesis of Cyclobutanes by Olefin [2 + 2] Photocycloaddition Reactions.

Authors:  Saner Poplata; Andreas Tröster; You-Quan Zou; Thorsten Bach
Journal:  Chem Rev       Date:  2016-03-28       Impact factor: 60.622

4.  Efficacy, plasma pharmacokinetics, and safety of icofungipen, an inhibitor of Candida isoleucyl-tRNA synthetase, in treatment of experimental disseminated candidiasis in persistently neutropenic rabbits.

Authors:  Ruta Petraitiene; Vidmantas Petraitis; Amy M Kelaher; Alia A Sarafandi; Diana Mickiene; Andreas H Groll; Tin Sein; John Bacher; Thomas J Walsh
Journal:  Antimicrob Agents Chemother       Date:  2005-05       Impact factor: 5.191

5.  Efficacy of PLD-118, a novel inhibitor of candida isoleucyl-tRNA synthetase, against experimental oropharyngeal and esophageal candidiasis caused by fluconazole-resistant C. albicans.

Authors:  Vidmantas Petraitis; Ruta Petraitiene; Amy M Kelaher; Alia A Sarafandi; Tin Sein; Diana Mickiene; John Bacher; Andreas H Groll; Thomas J Walsh
Journal:  Antimicrob Agents Chemother       Date:  2004-10       Impact factor: 5.191

Review 6.  Amino Acid Based Antimicrobial Agents - Synthesis and Properties.

Authors:  Michał G Nowak; Andrzej S Skwarecki; Maria J Milewska
Journal:  ChemMedChem       Date:  2021-10-01       Impact factor: 3.540

Review 7.  Amino Acid Metabolism and Transport Mechanisms as Potential Antifungal Targets.

Authors:  Matthew W McCarthy; Thomas J Walsh
Journal:  Int J Mol Sci       Date:  2018-03-19       Impact factor: 5.923

8.  Synthesis of Pyrrolo[1,2-a]pyrimidine Enantiomers via Domino Ring-Closure followed by Retro Diels-Alder Protocol.

Authors:  Beáta Fekete; Márta Palkó; Matti Haukka; Ferenc Fülöp
Journal:  Molecules       Date:  2017-04-13       Impact factor: 4.411

9.  Efficient continuous-flow synthesis of novel 1,2,3-triazole-substituted β-aminocyclohexanecarboxylic acid derivatives with gram-scale production.

Authors:  Sándor B Otvös; Adám Georgiádes; István M Mándity; Lóránd Kiss; Ferenc Fülöp
Journal:  Beilstein J Org Chem       Date:  2013-07-29       Impact factor: 2.883

10.  Efficient regio- and stereoselective access to novel fluorinated β-aminocyclohexanecarboxylates.

Authors:  Loránd Kiss; Melinda Nonn; Reijo Sillanpää; Santos Fustero; Ferenc Fülöp
Journal:  Beilstein J Org Chem       Date:  2013-06-17       Impact factor: 2.883
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