Literature DB >> 12565935

Synthesis and evaluation of delta-lactams (piperazones) as elastase inhibitors.

Jürgen Seibel1, David Brown, Augustin Amour, Simon J Macdonald, Neil J Oldham, Christopher J Schofield.   

Abstract

A series of monocyclic delta-lactams (piperazones) was prepared and analysed as inhibitors of porcine pancreatic elastase and human neutrophil elastase.

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Year:  2003        PMID: 12565935     DOI: 10.1016/s0960-894x(02)00995-2

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  Rapid, scalable assembly of stereochemically rich, mono- and bicyclic acyl sultams.

Authors:  Naeem Asad; Thiwanka B Samarakoon; Qin Zang; Joanna K Loh; Salim Javed; Paul R Hanson
Journal:  Org Lett       Date:  2013-12-06       Impact factor: 6.005

2.  Exploring the chemical space and the bioactivity profile of lactams: a chemoinformatic study.

Authors:  Fernanda I Saldívar-González; Elena Lenci; Andrea Trabocchi; José L Medina-Franco
Journal:  RSC Adv       Date:  2019-08-28       Impact factor: 3.361

  2 in total

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