Literature DB >> 12565922

Chemoenzymatic synthesis of high-mannose type HIV-1 gp120 glycopeptides.

Suddham Singh1, Jiahong Ni, Lai-Xi Wang.   

Abstract

A chemoenzymatic approach to the synthesis of glycoforms of HIV-1 gp120 glycopeptides is described. Thus, the high-mannose type glycopeptides [gp120 (336-342)] containing Man(9), Man(6) and Man(5) moieties, respectively, were synthesized in satisfactory yields via transglycosylation to the acetylglucosaminyl peptide, using the recombinant Arthrobacter Endo-beta-N-acetyl-glucosaminidase (Endo-A) as the key enzyme.

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Year:  2003        PMID： 12565922     DOI： 10.1016/s0960-894x(02)01025-9

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

1.  Expeditious chemoenzymatic synthesis of homogeneous N-glycoproteins carrying defined oligosaccharide ligands.

Authors:  Hirofumi Ochiai; Wei Huang; Lai-Xi Wang
Journal:  J Am Chem Soc       Date:  2008-09-20       Impact factor: 15.419

Review 2.  Anti-tumor and anti-viral activities of Galanthus nivalis agglutinin (GNA)-related lectins.

Authors:  Lei Wu; Jin-Ku Bao
Journal:  Glycoconj J       Date:  2012-08-15       Impact factor: 2.916

3.  De novo asymmetric synthesis of all-D-, all-L-, and D-/L-oligosaccharides using atom-less protecting groups.

Authors:  Ravula Satheesh Babu; Qian Chen; Sang-Woo Kang; Maoquan Zhou; George A O'Doherty
Journal:  J Am Chem Soc       Date:  2012-07-16       Impact factor: 15.419

Review 4.  Chemoenzymatic Methods for the Synthesis of Glycoproteins.

Authors:  Chao Li; Lai-Xi Wang
Journal:  Chem Rev       Date:  2018-08-24       Impact factor: 60.622

Review 5.  Chemoenzymatic synthesis of glycopeptides and glycoproteins through endoglycosidase-catalyzed transglycosylation.

Authors:  Lai-Xi Wang
Journal:  Carbohydr Res       Date:  2008-03-27       Impact factor: 2.104

6.  Chemoenzymatic synthesis and lectin array characterization of a class of N-glycan clusters.

Authors:  Wei Huang; Denong Wang; Masao Yamada; Lai-Xi Wang
Journal:  J Am Chem Soc       Date:  2009-12-16       Impact factor: 15.419

7.  Directed evolution of 2G12-targeted nonamannose glycoclusters by SELMA.

Authors:  J Sebastian Temme; Michael G Drzyzga; Iain S MacPherson; Isaac J Krauss
Journal:  Chemistry       Date:  2013-11-13       Impact factor: 5.236

8.  The Amazing Transglycosylation Activity of Endo-β-N-acetylglucosaminidases.

Authors:  Lai-Xi Wang
Journal:  Trends Glycosci Glycotechnol       Date:  2011       Impact factor: 1.083

9.  Glycosynthases enable a highly efficient chemoenzymatic synthesis of N-glycoproteins carrying intact natural N-glycans.

Authors:  Wei Huang; Cishan Li; Bing Li; Midori Umekawa; Kenji Yamamoto; Xinyu Zhang; Lai-Xi Wang
Journal:  J Am Chem Soc       Date:  2009-02-18       Impact factor: 15.419
  9 in total

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