Literature DB >> 12565801

Alpha-crystallin.

Joseph Horwitz1.   

Abstract

Alpha A and alpha B-crystallins are a major protein component of the mammalian eye lens. Being a member of the small heat-shock protein family they possess chaperone-like function. The alpha-crystallins and especially alpha B is also found outside the lens having an extensive tissue distribution. Alpha B-crystallin is found to be over-expressed in many neurological diseases, and mutations in alpha A or B-crystallin can cause cataract and myopathy. This review deals with some of the unique properties of the alpha-crystallins emphasizing especially what we don't know about its function and structure. Copyright 2003 Elsevier Science Ltd.

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Year:  2003        PMID： 12565801     DOI： 10.1016/s0014-4835(02)00278-6

Source DB:  PubMed          Journal:  Exp Eye Res        ISSN： 0014-4835            Impact factor:   3.467


  232 in total

1.  A transgenic mouse model for human autosomal dominant cataract.

Authors:  Cheng-Da Hsu; Steven Kymes; J Mark Petrash
Journal:  Invest Ophthalmol Vis Sci       Date:  2006-05       Impact factor: 4.799

2.  Therapeutic effects of systemic administration of chaperone αB-crystallin associated with binding proinflammatory plasma proteins.

Authors:  Jonathan B Rothbard; Michael P Kurnellas; Sara Brownell; Chris M Adams; Leon Su; Robert C Axtell; Rong Chen; C Garrison Fathman; William H Robinson; Lawrence Steinman
Journal:  J Biol Chem       Date:  2012-02-03       Impact factor: 5.157

3.  The orchestration of mammalian tissue morphogenesis through a series of coherent feed-forward loops.

Authors:  Qing Xie; Ales Cvekl
Journal:  J Biol Chem       Date:  2011-10-13       Impact factor: 5.157

4.  Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function.

Authors:  Arthur Laganowsky; Justin L P Benesch; Meytal Landau; Linlin Ding; Michael R Sawaya; Duilio Cascio; Qingling Huang; Carol V Robinson; Joseph Horwitz; David Eisenberg
Journal:  Protein Sci       Date:  2010-05       Impact factor: 6.725

5.  Tight binding of proteins to membranes from older human cells.

Authors:  Roger J W Truscott; Susana Comte-Walters; Zsolt Ablonczy; John H Schwacke; Yoke Berry; Anastasia Korlimbinis; Michael G Friedrich; Kevin L Schey
Journal:  Age (Dordr)       Date:  2010-12-23

Review 6.  Novel roles for α-crystallins in retinal function and disease.

Authors:  Ram Kannan; Parameswaran G Sreekumar; David R Hinton
Journal:  Prog Retin Eye Res       Date:  2012-06-18       Impact factor: 21.198

7.  Electron tomography of fiber cell cytoplasm and dense cores of multilamellar bodies from human age-related nuclear cataracts.

Authors:  M Joseph Costello; Alain Burette; Mariko Weber; Sangeetha Metlapally; Kurt O Gilliland; W Craig Fowler; Ashik Mohamed; Sönke Johnsen
Journal:  Exp Eye Res       Date:  2012-06-20       Impact factor: 3.467

8.  RNA aptamers targeted for human αA-crystallin do not bind αB-crystallin, and spare the α-crystallin domain.

Authors:  Prabhat K Mallik; Hua Shi; Jayanti Pande
Journal:  Biochem Biophys Res Commun       Date:  2017-07-15       Impact factor: 3.575

9.  Effect of site-directed mutagenesis of methylglyoxal-modifiable arginine residues on the structure and chaperone function of human alphaA-crystallin.

Authors:  Ashis Biswas; Antonia Miller; Tomoko Oya-Ito; Puttur Santhoshkumar; Manjunatha Bhat; Ram H Nagaraj
Journal:  Biochemistry       Date:  2006-04-11       Impact factor: 3.162

10.  Increased ocular levels of IGF-1 in transgenic mice lead to diabetes-like eye disease.

Authors:  Jesús Ruberte; Eduard Ayuso; Marc Navarro; Ana Carretero; Víctor Nacher; Virginia Haurigot; Mónica George; Cristina Llombart; Alba Casellas; Cristina Costa; Assumpció Bosch; Fatima Bosch
Journal:  J Clin Invest       Date:  2004-04       Impact factor: 14.808
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