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Literature DB >> 12565133

Temporal regulation of CD81 following retinal injury in the rat.

Bong Keun Song¹, Grace R Geisert, Felix Vázquez-Chona, Eldon E Geisert.

Abstract

Following retinal injury, glial cells within the retina undergo a response that is characterized by the proliferation of astrocytes, Müller cells, and retinal pigment epithelial cells. CD81, a small membrane protein known to be involved in cell proliferation, is up-regulated after injury. This study focuses on the temporal regulation of CD81, relating the expression of this protein to glial fibrillary acidic protein (GFAP), the classic marker of gliosis. CD81 levels were elevated at 7 days after injury and remained elevated at 30 days after injury; GFAP was increased at 7 days and continued to increase until 30 days post injury. This association of CD81 with glial reactivity may provide a clue to the regulation of the proliferative response following retinal injury. Copyright 2002 Elsevier Science Ireland Ltd.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2003 PMID： 12565133 PMCID： PMC2814056 DOI： 10.1016/s0304-3940(02)01364-2

Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046

20 in total

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Authors: S K Fisher; P A Erickson; G P Lewis; D H Anderson
Journal: Invest Ophthalmol Vis Sci Date: 1991-05 Impact factor: 4.799

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Authors: R E MacLaren
Journal: Br J Ophthalmol Date: 1996-05 Impact factor: 4.638

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Authors: C Guidry
Journal: Invest Ophthalmol Vis Sci Date: 1997-02 Impact factor: 4.799

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Authors: E E Geisert; A M Stewart
Journal: Dev Biol Date: 1991-02 Impact factor: 3.582

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Authors: P V Sarthy; M Fu; J Huang
Journal: Cell Mol Neurobiol Date: 1991-12 Impact factor: 5.046

6. A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase.

Authors: F Berditchevski; K F Tolias; K Wong; C L Carpenter; M E Hemler
Journal: J Biol Chem Date: 1997-01-31 Impact factor: 5.157

Temporal regulation of CD81 following retinal injury in the rat.

1. Intraretinal proliferation induced by retinal detachment.

2. Development and role of retinal glia in regeneration of ganglion cells following retinal injury.

3. Tractional force generation by porcine Müller cells. Development and differential stimulation by growth factors.

4. Changing interactions between astrocytes and neurons during CNS maturation.

5. Developmental expression of the glial fibrillary acidic protein (GFAP) gene in the mouse retina.

6. A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase.

7. Changes in the expression of specific Müller cell proteins during long-term retinal detachment.

8. TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins.

9. Neuronal and neuroglial responses following retinal lesions in the neonatal rats.

10. Proliferative vitreoretinopathy. The mechanism of development of vitreoretinal traction.

1. Temporal changes in gene expression after injury in the rat retina.

2. Mechanobiological responses of astrocytes in optic nerve head due to biaxial stretch.