Literature DB >> 12563310

The endothelin axis: emerging role in cancer.

Joel Nelson1, Anna Bagnato, Bruno Battistini, Perry Nisen.   

Abstract

Collectively, the endothelins and their receptors--referred to as the endothelin (ET) axis--have key physiological functions in normal tissue, acting as modulators of vasomotor tone, tissue differentiation, development, cell proliferation and hormone production. Based on new data, the ET axis also functions in the growth and progression of various tumours. Preliminary results from clinical trials, such as those with atrasentan--an ET(A)-receptor antagonist--in prostate cancer, are encouraging. The place of ET-receptor antagonists in cancer therapy for a range of malignancies merits further investigation.

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Year:  2003        PMID： 12563310     DOI： 10.1038/nrc990

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  153 in total

Review 1.  Mechanism of cancer pain.

Authors:  Brian L Schmidt; Darryl T Hamamoto; Donald A Simone; George L Wilcox
Journal:  Mol Interv       Date:  2010-06

Review 2.  Early progress in epigenetic regulation of endothelin pathway genes.

Authors:  A K Welch; M E Jacobs; C S Wingo; B D Cain
Journal:  Br J Pharmacol       Date:  2013-01       Impact factor: 8.739

3.  Rendomab B4, a monoclonal antibody that discriminates the human endothelin B receptor of melanoma cells and inhibits their migration.

Authors:  Aurélie Borrull; Bertrand Allard; Anne Wijkhuisen; Amaury Herbet; Patricia Lamourette; Wided Birouk; Denis Leiber; Zahra Tanfin; Frédéric Ducancel; Didier Boquet; Jean-Yves Couraud; Philippe Robin
Journal:  MAbs       Date:  2016-07-08       Impact factor: 5.857

4.  Lactoferrin-endothelin-1 axis contributes to the development and invasiveness of triple-negative breast cancer phenotypes.

Authors:  Ngoc-Han Ha; Vasudha S Nair; Divijendra Natha Sirigiri Reddy; Prakriti Mudvari; Kazufumi Ohshiro; Krishna Sumanth Ghanta; Suresh B Pakala; Da-Qiang Li; Luis Costa; Allan Lipton; Rajendra A Badwe; Suzanne Fuqua; Margaretha Wallon; George C Prendergast; Rakesh Kumar
Journal:  Cancer Res       Date:  2011-10-17       Impact factor: 12.701

5.  Tumor endothelin-1 enhances metastatic colonization of the lung in mouse xenograft models of bladder cancer.

Authors:  Neveen Said; Steven Smith; Marta Sanchez-Carbayo; Dan Theodorescu
Journal:  J Clin Invest       Date:  2010-12-22       Impact factor: 14.808

Review 6.  Endothelin receptor antagonists.

Authors:  Joel B Nelson
Journal:  World J Urol       Date:  2005-01-15       Impact factor: 4.226

Review 7.  Metastasis suppressor proteins: discovery, molecular mechanisms, and clinical application.

Authors:  Carrie W Rinker-Schaeffer; James P O'Keefe; Danny R Welch; Dan Theodorescu
Journal:  Clin Cancer Res       Date:  2006-07-01       Impact factor: 12.531

8.  Inhibitory effect of endothelin A receptor blockade on tumor growth and liver metastasis of a human gastric cancer cell line.

Authors:  Rika Fukui; Hidefumi Nishimori; Fumitake Hata; Takahiro Yasoshima; Keisuke Ohno; Yoshiyuki Yanai; Kenjiro Kamiguchi; Ryuichi Denno; Noriyuki Sato; Koichi Hirata
Journal:  Gastric Cancer       Date:  2007-06-25       Impact factor: 7.370

9.  The endothelin-integrin axis is involved in macrophage-induced breast cancer cell chemotactic interactions with endothelial cells.

Authors:  Chia-Chi Chen; Li-Li Chen; Yu-Ting Hsu; Ko-Jiunn Liu; Chi-Shuan Fan; Tze-Sing Huang
Journal:  J Biol Chem       Date:  2014-02-18       Impact factor: 5.157

10.  Endothelin antagonism in portal hypertensive mice: implications for endothelin receptor-specific signaling in liver disease.

Authors:  Hong-Qiang Feng; Nate D Weymouth; Don C Rockey
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2009-03-19       Impact factor: 4.052
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