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Literature DB >> 12563307

Protein folding and disease: a view from the first Horizon Symposium.

Christopher M Dobson¹.

Abstract

Mesh：

Substances：
Proteins

Year: 2003 PMID： 12563307 DOI： 10.1038/nrd1013

Source DB: PubMed Journal: Nat Rev Drug Discov ISSN： 1474-1776 Impact factor: 84.694

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Cited

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29 in total

1. Protein aggregation/folding: the role of deterministic singularities of sequence hydrophobicity as determined by nonlinear signal analysis of acylphosphatase and Abeta(1-40).

Authors: Joseph P Zbilut; Alfredo Colosimo; Filippo Conti; Mauro Colafranceschi; Cesare Manetti; MariaCristina Valerio; Charles L Webber; Alessandro Giuliani
Journal: Biophys J Date: 2003-12 Impact factor: 4.033

2. Structures and relative free energies of partially folded states of proteins.

Authors: Michele Vendruscolo; Emanuele Paci; Martin Karplus; Christopher M Dobson
Journal: Proc Natl Acad Sci U S A Date: 2003-12-01 Impact factor: 11.205

3. Short amino acid stretches can mediate amyloid formation in globular proteins: the Src homology 3 (SH3) case.

Authors: Salvador Ventura; Jesús Zurdo; Saravanakumar Narayanan; Matilde Parreño; Ramón Mangues; Bernd Reif; Fabrizio Chiti; Elisa Giannoni; Christopher M Dobson; Francesc X Aviles; Luis Serrano
Journal: Proc Natl Acad Sci U S A Date: 2004-05-03 Impact factor: 11.205

Protein folding and disease: a view from the first Horizon Symposium.

1. Protein aggregation/folding: the role of deterministic singularities of sequence hydrophobicity as determined by nonlinear signal analysis of acylphosphatase and Abeta(1-40).

2. Structures and relative free energies of partially folded states of proteins.

3. Short amino acid stretches can mediate amyloid formation in globular proteins: the Src homology 3 (SH3) case.

4. The stability and dynamics of the human calcitonin amyloid peptide DFNKF.

5. Influence of denatured and intermediate states of folding on protein aggregation.

6. Metalloendoprotease cleavage triggers gelsolin amyloidogenesis.

Review 7. The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy.

8. Common attributes of native-state structures of proteins, disordered proteins, and amyloid.

9. Symmetry, shape, and order.

10. Role of oxygen consumption in hypoxia protection by translation factor depletion.