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Literature DB >> 12563277

Native Myosin-IXb is a plus-, not a minus-end-directed motor.

Christopher B O'Connell¹, Mark S Mooseker.

Abstract

Myosin-IXb (Myo9b) is a single-headed, processive motor that contains a Rho-GTPase-activating protein (GAP) domain within its tail. Although tail-less myosin- IXb motor domain moves towards the minus end of the actin filament, we show here that full-length myosin-IXb is a plus-end-directed motor. This suggests that the tail domain of myosin-IXb regulates motor directionality.

Entities: Gene

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Year: 2003 PMID： 12563277 DOI： 10.1038/ncb924

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

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Cited

12 in total

1. Head of myosin IX binds calmodulin and moves processively toward the plus-end of actin filaments.

Authors: Wanqin Liao; Kerstin Elfrink; Martin Bähler
Journal: J Biol Chem Date: 2010-06-10 Impact factor: 5.157

2. Plus-end directed myosins accelerate actin filament sliding by single-headed myosin VI.

Authors: Bhagavathi Ramamurthy; Wenxiang Cao; Enrique M De la Cruz; Mark S Mooseker
Journal: Cytoskeleton (Hoboken) Date: 2012-01-09

3. Motorized RhoGAP myosin IXb (Myo9b) controls cell shape and motility.

Authors: Peter J Hanley; Yan Xu; Moritz Kronlage; Kay Grobe; Peter Schön; Jian Song; Lydia Sorokin; Albrecht Schwab; Martin Bähler
Journal: Proc Natl Acad Sci U S A Date: 2010-06-21 Impact factor: 11.205

4. The Myosin IXb motor activity targets the myosin IXb RhoGAP domain as cargo to sites of actin polymerization.

Authors: Frank van den Boom; Heiko Düssmann; Katharina Uhlenbrock; Marouan Abouhamed; Martin Bähler
Journal: Mol Biol Cell Date: 2007-02-21 Impact factor: 4.138

5. Myosin VI is required for maintenance of brush border structure, composition, and membrane trafficking functions in the intestinal epithelial cell.

Authors: Peter S Hegan; Hector Giral; Moshe Levi; Mark S Mooseker
Journal: Cytoskeleton (Hoboken) Date: 2012-03-02

Native Myosin-IXb is a plus-, not a minus-end-directed motor.

1. Head of myosin IX binds calmodulin and moves processively toward the plus-end of actin filaments.

2. Plus-end directed myosins accelerate actin filament sliding by single-headed myosin VI.

3. Motorized RhoGAP myosin IXb (Myo9b) controls cell shape and motility.

4. The Myosin IXb motor activity targets the myosin IXb RhoGAP domain as cargo to sites of actin polymerization.

5. Myosin VI is required for maintenance of brush border structure, composition, and membrane trafficking functions in the intestinal epithelial cell.

Review 6. Myosin VI: cellular functions and motor properties.

7. Noncanonical Myo9b-RhoGAP Accelerates RhoA GTP Hydrolysis by a Dual-Arginine-Finger Mechanism.

Review 8. Myosin VI: an innovative motor that challenged the swinging lever arm hypothesis.

9. Engineered myosin VI motors reveal minimal structural determinants of directionality and processivity.

10. A role for myosin IXb, a motor-RhoGAP chimera, in epithelial wound healing and tight junction regulation.