Literature DB >> 12562715

Ex vivo synergy of arachidonate-enriched serum with ceftazidime and amikacin on multidrug-resistant Pseudomonas aeruginosa.

Evangelos J Giamarellos-Bourboulis1, Diamantis Plachouras, Sotirios Skiathitis, Maria Raftogiannis, Amalia Dionyssiou-Asteriou, Ismini Dontas, Panayotis E Karayannacos, Helen Giamarellou.   

Abstract

Three multidrug-resistant strains of Pseudomonas aeruginosa were incubated ex vivo with sera sampled after a 10 min intravenous infusion of 25 mg/kg of arachidonic acid (AA) in 10 rabbits in the presence of ceftazidime and amikacin. Lipid peroxidation was assessed during bacterial growth. A statistically significant decrease in bacterial cells was found by the interaction of antimicrobials and serum sampled in the middle of infusion and 15 and 30 min after infusion of AA and was accompanied by elevated levels of malonodialdehyde. This effect of AA is probably attributed to lipid peroxidation and raises the possibility of its application in experimental infections.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 12562715     DOI： 10.1093/jac/dkg026

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  4 in total

1.  n-6 polyunsaturated fatty acids enhance the activities of ceftazidime and amikacin in experimental sepsis caused by multidrug-resistant Pseudomonas aeruginosa.

Authors:  Evangelos J Giamarellos-Bourboulis; Maria Mouktaroudi; Theodoros Adamis; Vassilios Koussoulas; Fotini Baziaka; Despina Perrea; Panayotis E Karayannacos; Helen Giamarellou
Journal:  Antimicrob Agents Chemother       Date:  2004-12       Impact factor: 5.191

2.  Lipids including cholesteryl linoleate and cholesteryl arachidonate contribute to the inherent antibacterial activity of human nasal fluid.

Authors:  Thai Q Do; Safiehkhatoon Moshkani; Patricia Castillo; Suda Anunta; Adelina Pogosyan; Annie Cheung; Beth Marbois; Kym F Faull; William Ernst; Su Ming Chiang; Gary Fujii; Catherine F Clarke; Krishna Foster; Edith Porter
Journal:  J Immunol       Date:  2008-09-15       Impact factor: 5.422

3.  Complement-dependent outer membrane perturbation sensitizes Gram-negative bacteria to Gram-positive specific antibiotics.

Authors:  D A C Heesterbeek; N I Martin; A Velthuizen; M Duijst; M Ruyken; R Wubbolts; S H M Rooijakkers; B W Bardoel
Journal:  Sci Rep       Date:  2019-02-28       Impact factor: 4.379

4.  Serum apolipoprotein A-I potentiates the therapeutic efficacy of lysocin E against Staphylococcus aureus.

Authors:  Hiroshi Hamamoto; Suresh Panthee; Atmika Paudel; Kenichi Ishii; Jyunichiro Yasukawa; Jie Su; Atsushi Miyashita; Hiroaki Itoh; Kotaro Tokumoto; Masayuki Inoue; Kazuhisa Sekimizu
Journal:  Nat Commun       Date:  2021-11-04       Impact factor: 14.919
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.