Literature DB >> 12562088

Herbal remedies traditionally used against malaria in Ghana: bioassay-guided fractionation of Microglossa pyrifolia (Asteraceae).

Inga Köhler1, Kristina Jenett-Siems, Carola Kraft, Karsten Siems, Daniel Abbiw, Ulrich Bienzle, Eckart Eich.   

Abstract

Different extracts from 11 West African plants traditionally used against malaria in Ghana were tested against both the chloroquine-sensitive strain PoW and the chloroquine-resistant clone Dd2 of Plasmodium falciparum. Due to the promising in vitro activity of the lipophilic extract [IC50: 10.5 microg/ml (PoW); 13.1 microg/ml (Dd2)], Microglossa pyrifolia (Lam.) Kuntze (Asteraceae) was chosen for further phytochemical investigation. From active fractions 13 compounds were isolated; their structures were established on the basis of spectroscopic methods. 1-Acetyl-6E-geranylgeraniol-19-oic acid and sinapyl diangelate represent new natural compounds. The two diterpenes E-phytol [IC50: 8.5 microM (PoW); 11.5 microM (Dd2)], and 6E-geranylgeraniol-19-oic acid [IC50: 12.9 microM (PoW); 15.6 microM (Dd2)] proved to be the most active constituents in our test system.

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Year:  2002        PMID： 12562088     DOI： 10.1515/znc-2002-11-1212

Source DB:  PubMed          Journal:  Z Naturforsch C J Biosci        ISSN： 0341-0382


  9 in total

1.  Comparison of SYBR Green I-, PicoGreen-, and [3H]-hypoxanthine-based assays for in vitro antimalarial screening of plants from Nigerian ethnomedicine.

Authors:  Oyindamola O Abiodun; Grace O Gbotosho; Edith O Ajaiyeoba; Christian T Happi; Sandra Hofer; Sergio Wittlin; Akin Sowunmi; Reto Brun; Ayoade M J Oduola
Journal:  Parasitol Res       Date:  2010-02-18       Impact factor: 2.289

Review 2.  Medicinal Plants with Prospective Benefits in the Management of Peptic Ulcer Diseases in Ghana.

Authors:  Mavis Boakye-Yiadom; Doris Kumadoh; Emmanuel Adase; Eric Woode
Journal:  Biomed Res Int       Date:  2021-05-05       Impact factor: 3.411

3.  Ethnodiagnostic skills of the digo community for malaria: a lead to traditional bioprospecting.

Authors:  Joseph Mwanzia Nguta; James M Mbaria; Peter K Gathumbi; Daniel Gakuya; John David Kabasa; Stephen Gitahi Kiama
Journal:  Front Pharmacol       Date:  2011-06-24       Impact factor: 5.810

Review 4.  Ethnopharmacological Survey of Plants Used in the Traditional Treatment of Gastrointestinal Pain, Inflammation and Diarrhea in Africa: Future Perspectives for Integration into Modern Medicine.

Authors:  Timo D Stark; Dorah J Mtui; Onesmo B Balemba
Journal:  Animals (Basel)       Date:  2013-03-04       Impact factor: 2.752

5.  Evaluation of Senna singueana leaf extract as an alternative or adjuvant therapy for malaria.

Authors:  Mebrahtom Gebrelibanos Hiben; Gereziher Gebremedhin Sibhat; Biruk Sintayehu Fanta; Haile Desta Gebrezgi; Shewaye Belay Tesema
Journal:  J Tradit Complement Med       Date:  2015-01-22

6.  Medicinal plants used for management of malaria among the Luhya community of Kakamega East sub-County, Kenya.

Authors:  Nillian Mukungu; Kennedy Abuga; Faith Okalebo; Raphael Ingwela; Julius Mwangi
Journal:  J Ethnopharmacol       Date:  2016-08-30       Impact factor: 4.360

Review 7.  Antimalarial Activity of Plant Metabolites.

Authors:  Wen-Hui Pan; Xin-Ya Xu; Ni Shi; Siu Wai Tsang; Hong-Jie Zhang
Journal:  Int J Mol Sci       Date:  2018-05-06       Impact factor: 5.923

Review 8.  Antimalarial Plants Used across Kenyan Communities.

Authors:  Timothy Omara
Journal:  Evid Based Complement Alternat Med       Date:  2020-06-12       Impact factor: 2.629

9.  Ethnobotanical study of plants used by the traditional healers to treat malaria in Mogovolas district, northern Mozambique.

Authors:  Leonardo Manuel; Aurélio Bechel; Emília Virgínia Noormahomed; Delfina Fernandes Hlashwayo; Maria do Céu Madureira
Journal:  Heliyon       Date:  2020-12-18
  9 in total

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