Literature DB >> 12561253

Two flavones from Scutellaria baicalensis Georgi and their binding affinities to the benzodiazepine site of the GABAA receptor complex.

Hongyan Wang1, Kwok-Min Hui, Suixu Xu, Yingjie Chen, J Tze Fei Wong, Hong Xue.   

Abstract

A new flavone 6,2'-dihydroxy-5,7,8,6'-tetramethoxyflavone (1) together with one known flavone 5,7,2'-trihydroxy-6,8-dimethoxyflavone (2) were isolated from the roots of Scutellaria baicalensis Georgi. Their structures were elucidated on the basis of spectral evidence and their affinities for the benzodiazepine (BDZ) site of the GABAA receptor complex were evaluated with a radioligand receptor binding assay.

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Year:  2002        PMID: 12561253

Source DB:  PubMed          Journal:  Pharmazie        ISSN: 0031-7144            Impact factor:   1.267


  3 in total

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2.  The Attenuation of Scutellariae radix Extract on Oxidative Stress for Colon Injury in Lipopolysaccharide-induced RAW264.7 Cell and 2,4,6-trinitrobenzene Sulfonic Acid-induced Ulcerative Colitis Rats.

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Journal:  Pharmacogn Mag       Date:  2016 Apr-Jun       Impact factor: 1.085

3.  Involvement of the GABAergic system in the neuroprotective and sedative effects of acacetin 7-O-glucoside in rodents.

Authors:  Javier Gálvez; Rosa Estrada-Reyes; Gloria Benítez-King; Gabriela Araujo; Sandra Orozco; Rodrigo Fernández-Mas; Salvador Almazán; Eduardo Calixto
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  3 in total

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