PURPOSE: The levels of thyroid hormones decrease in septic, critically ill, and major trauma patients who show a bad prognosis. The aim of this study was to investigate the effects of thyroid hormone supplementation on the sepsis criteria and mortality in an experimental sepsis model. METHODS: Forty-eight Wistar-Albino rats were divided into four experimental groups. A cecum ligation and puncture was used as a sepsis model. Group I: sham; group II: a cecum ligation and puncture (control); group III: a cecum ligation and puncture +T3 (0.4 microg/100 g body weight/day) intraperitoneally; group IV: a cecum ligation and puncture +T4 (1 500 ng/100 g body weight/day) intramuscularly. The PCO(2), leukocyte count, peritoneal bacterial content, neutropenia, and mortality rates were assessed in all groups. RESULTS: The PCO(2) levels decreased only in the control group ( P < 0.05). The leukocyte counts were lower in the therapy groups ( P < 0.05). The rate of neutropenia was seen much more in the control group ( P < 0.05). The peritoneal bacteria content decreased in the therapy groups ( P < 0.05). The mortality rate significantly decreased in the thyroid hormone-treated animals ( P < 0.05). CONCLUSIONS: Thyroid hormone supplementation in septic rats had a beneficial effect on the sepsis criteria and also resulted in a lower rate of mortality.
PURPOSE: The levels of thyroid hormones decrease in septic, critically ill, and major traumapatients who show a bad prognosis. The aim of this study was to investigate the effects of thyroid hormone supplementation on the sepsis criteria and mortality in an experimental sepsis model. METHODS: Forty-eight Wistar-Albino rats were divided into four experimental groups. A cecum ligation and puncture was used as a sepsis model. Group I: sham; group II: a cecum ligation and puncture (control); group III: a cecum ligation and puncture +T3 (0.4 microg/100 g body weight/day) intraperitoneally; group IV: a cecum ligation and puncture +T4 (1 500 ng/100 g body weight/day) intramuscularly. The PCO(2), leukocyte count, peritoneal bacterial content, neutropenia, and mortality rates were assessed in all groups. RESULTS: The PCO(2) levels decreased only in the control group ( P < 0.05). The leukocyte counts were lower in the therapy groups ( P < 0.05). The rate of neutropenia was seen much more in the control group ( P < 0.05). The peritoneal bacteria content decreased in the therapy groups ( P < 0.05). The mortality rate significantly decreased in the thyroid hormone-treated animals ( P < 0.05). CONCLUSIONS: Thyroid hormone supplementation in septic rats had a beneficial effect on the sepsis criteria and also resulted in a lower rate of mortality.
Authors: Olga Barca-Mayo; Xiao-Hui Liao; Caterina DiCosmo; Alexandra Dumitrescu; Liliana Moreno-Vinasco; Michael S Wade; Saad Sammani; Tamara Mirzapoiazova; Joe G N Garcia; Samuel Refetoff; Roy E Weiss Journal: Proc Natl Acad Sci U S A Date: 2011-11-07 Impact factor: 11.205
Authors: Gábor Wittmann; John W Harney; Praful S Singru; Shira S Nouriel; P Reed Larsen; Ronald M Lechan Journal: Endocrinology Date: 2014-03-06 Impact factor: 4.736
Authors: Shwu-Fan Ma; Lishi Xie; Maria Pino-Yanes; Saad Sammani; Michael S Wade; Eleftheria Letsiou; Jessica Siegler; Ting Wang; Giovanni Infusino; Rick A Kittles; Carlos Flores; Tong Zhou; Bellur S Prabhakar; Liliana Moreno-Vinasco; Jesus Villar; Jeffrey R Jacobson; Steven M Dudek; Joe G N Garcia Journal: Am J Respir Cell Mol Biol Date: 2011-06-17 Impact factor: 6.914