| Literature DB >> 12560170 |
Kenneth A Beattie1, Judith Ressler, Claudia Wiegand, Eberhard Krause, Geoffrey A Codd, Christian E W Steinberg, Stephan Pflugmacher.
Abstract
The toxicity and metabolism of the cyanobacterial toxins microcystin-LR (MCLR), Dhb-microcystin-HtyR and nodularin were investigated in the cysts, nauplii and adults of the brine shrimp Artemia salina. The presence of the phase II detoxication system glutathione S-transferase (sGST) in these stages was shown using different substrates. Exposure of adult A. salina to the toxins led to an elevation of GST activity in vivo. All three toxins were conjugated to glutathione via GST, which has been shown as an initial step of microcystin and nodularin detoxication.Entities:
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Year: 2003 PMID： 12560170 DOI： 10.1016/s0166-445x(02)00091-7
Source DB: PubMed Journal: Aquat Toxicol ISSN： 0166-445X Impact factor: 4.964